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Protein Overview: IL4

General Information:
Name(s) found: IL4 [HGNC (HUGO)]
Description(s) found:
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  • pir||A25946 interleukin-4 precursor - human [NCBI NR]
  • gi|47123367|gb|AAH70123.1| Interleukin 4 [Homo sapiens] [NCBI NR]
  • gi|45708996|gb|AAH67514.1| Interleukin 4 [Homo sapiens] [NCBI NR]
  • gi|4504669|ref|NP_000580.1| interleukin 4 isoform 1 precursor [Homo sapiens] [NCBI NR]
  • gi|307061|gb|AAA59149.1| interleukin 4 [Homo sapiens] [NCBI NR]
  • gi|186337|gb|AAA59150.1| interleukin 4 [Homo sapiens] [NCBI NR]
  • gi|14600280|gb|AAK71324.1|AF395008_1 interleukin 4 [Homo sapiens] [NCBI NR]
  • gi|124337|sp|P05112.1|IL4_HUMAN RecName: Full=Interleukin-4; Short=IL-4; AltName: Full=B-cell stimulatory factor 1; Short=BSF-1; AltName: Full=Lymphocyte stimulatory factor 1; AltName: Full=Binetrakin; AltName: Full=Pitrakinra; Flags: Precursor [NCBI NR]
  • gi|119582726|gb|EAW62322.1| interleukin 4, isoform CRA_a [Homo sapiens] [NCBI NR]
  • interleukin 4 [HGNC (HUGO)]
  • Interleukin-4 OS=Homo sapiens GN=IL4 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform Long of P05112 [hmr_yeast5_DM3-1_pombe.fasta]
  • interleukin 4 isoform 1 precursor; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1 [HMR_022704.fasta]
  • interleukin 4 isoform 1 precursor [Homo sapiens]gi|47123367|gb|AAH70123.1| Interleukin 4, isoform 1 precursor [Homo sapiens]gi|45708996|gb|AAH67514.1| Interleukin 4, isoform 1 precursor [Homo sapiens]gi|47117806|sp|Q8HYB1|IL4_PANTR Interleukin-4 precur [nrdb_11152004_Chlamydomonas]
  • Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Interleukin-4 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000589) interleukin 4 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • interleukin 4 isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Long of Interleukin-4 precursor [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • interleukin 4 isoform 1 precursor; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1) (Binetrakin) (Pitrakinra) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • interleukin 4, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Interleukin 4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • interleukin 4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Interleukin-4 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF INTERLEUKIN-4 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=IL4 Isoform 1 of Interleukin-4 [human-ipi-250309-contam.fasta]
  • IPI:IPI00007081.1|SWISS-PROT:P05112-1|TREMBL:A1Z2K1;B0JFA2;Q6NWP0;Q6NZ77|ENSEMBL:ENSP00000231449|REFSEQ:NP_000580|H-INV:HIT000194286|VEGA:OTTHUMP00000066049 Tax_Id=9606 Gene_Symbol=IL4 Isoform 1 of Interleukin-4 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=IL4 Isoform 1 of Interleukin-4 precursor ENSG00000113520 IPI00007081 IPI00217945 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=IL4 Isoform 1 of Interleukin-4 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • interleukin-4 isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P05112;Q14630; RecName: Full=Interleukin-4; AltName: Full=B-cell stimulatory factor 1; AltName: Full=Lymphocyte stimulatory factor 1; AltName: Full=Binetrakin; AltName: Full=Pitrakinra; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Interleukin-4 OS=Homo sapiens GN=IL4 [011711_HMR.fasta]
  • GeneSymbol=IL4 Synonyms=BCGF-1|BCGF1|BSF-1|BSF1|IL-4|MGC79402 interleukin-4 isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00007081.1|SWISS-PROT:P05112-1|TREMBL:A1Z2K1;B0JFA2;D4HNR6;Q6NWP0;Q6NZ77|ENSEMBL:ENSP00000231449|REFSEQ:NP_000580|H-INV:HIT000194286|VEGA:OTTHUMP00000066049 Tax_Id=9606 Gene_Symbol=IL4 Isoform 1 of Interleukin-4 [ipi.HUMAN.20110912.fasta]
  • Interleukin-4 GN=IL4 [Doctor+uniprot-HUMAN-120911.fasta]
  • Interleukin 4 OS=Homo sapiens GN=IL4 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 153 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS  60
   61 KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL 120
  121 NSCPVKEANQ STLENFLERL KTIMREKYSK CSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 53.69897 HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • cytokine activity
    		•  6.38439864086716 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • growth factor activity
    		•  4.92105782010612 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  3.27756723691542 bayes_pls_golite062009
  • protein binding
    		•  3.26483713001551 bayes_pls_golite062009
  • interleukin-4 receptor binding
    		•  3.17951022946458 bayes_pls_golite062009
  • growth hormone activity
    		•  2.71439518801599 bayes_pls_golite062009
  • binding
    		•  2.48265117231403 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  2.37535614986843 bayes_pls_golite062009
  • hormone activity
    		•  2.25587306265428 bayes_pls_golite062009
  • interleukin-12 binding
    		•  2.17594406686308 bayes_pls_golite062009
  • interleukin-27 binding
    		•  1.83998174953013 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.79326213321183 bayes_pls_golite062009
  • interleukin-2 receptor binding
    		•  1.24568403220915 bayes_pls_golite062009
  • interleukin-12 beta subunit binding
    		•  1.10825259714222 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  0.77580300541347 bayes_pls_golite062009
  • interleukin-3 receptor binding
    		•  0.264629367313661 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  0.218984052557791 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.010318258615897 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle