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Protein Overview: HMGCL

General Information:
Name(s) found: HMGCL [HGNC (HUGO)]
Description(s) found:
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  • gi|62198232|ref|NP_000182.2| 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens] [NCBI NR]
  • gi|48145885|emb|CAG33165.1| HMGCL [Homo sapiens] [NCBI NR]
  • gi|32879927|gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) [Homo sapiens] [NCBI NR]
  • gi|24418852|sp|P35914.2|HMGCL_HUMAN RecName: Full=Hydroxymethylglutaryl-CoA lyase, mitochondrial; Short=HMG-CoA lyase; Short=HL; AltName: Full=3-hydroxy-3-methylglutarate-CoA lyase; Flags: Precursor [NCBI NR]
  • gi|189054090|dbj|BAG36597.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|14714839|gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Homo sapiens] [NCBI NR]
  • gi|119615500|gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria), isoform CRA_a [Homo sapiens] [NCBI NR]
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase [HGNC (HUGO)]
  • (P35914) Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) [Swiss-Prot]
  • Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens GN=HMGCL PE=1 SV=2 [Swiss-Prot]
  • Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) [Homo sapiens]gi|14714839|gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) [Homo sapiens]gi|24418852|sp|P35914|HMGL_HUMAN H [nrdb_11152004_Chlamydomonas]
  • Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • HMGCL [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HYDROXYMETHYLGLUTARYL-COA LYASE, MITOCHONDRIAL PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial [human-ipi-250309-contam.fasta]
  • 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl CoA lyase isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00293564.5|SWISS-PROT:P35914|TREMBL:B1AK13;Q6IBC0|ENSEMBL:ENSP00000235958;ENSP00000363611;ENSP00000363614|REFSEQ:NP_000182|H-INV:HIT000304123|VEGA:OTTHUMP00000003004;OTTHUMP00000003005 Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor ENSG00000117305 IPI00514742 IPI00293564 IPI00514407 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P35914;Q96FP8; RecName: Full=Hydroxymethylglutaryl-CoA lyase, mitochondrial; AltName: Full=3-hydroxy-3-methylglutarate-CoA lyase; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens GN=HMGCL [011711_HMR.fasta]
  • IPI:IPI00293564.5|SWISS-PROT:P35914|TREMBL:B1AK13;Q6IBC0|ENSEMBL:ENSP00000235958;ENSP00000363611;ENSP00000363614|REFSEQ:NP_000182|H-INV:HIT000304123|VEGA:OTTHUMP00000003004;OTTHUMP00000003005 Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=HMGCL Synonyms=HL hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00293564.5|SWISS-PROT:P35914|TREMBL:Q6IBC0|ENSEMBL:ENSP00000363614|REFSEQ:NP_000182|H-INV:HIT000304123|VEGA:OTTHUMP00000003005 Tax_Id=9606 Gene_Symbol=HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial [ipi.HUMAN.20110912.fasta]
  • Hydroxymethylglutaryl-CoA lyase, mitochondrial GN=HMGCL [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI VSTPVKIKLI  60
   61 DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG INYPVLTPNL KGFEAAVAAG 120
  121 AKEVVIFGAA SELFTKKNIN CSIEESFQRF DAILKAAQSA NISVRGYVSC ALGCPYEGKI 180
  181 SPAKVAEVTK KFYSMGCYEI SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ 240
  241 ALANTLMALQ MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL 300
  301 EAGNFICQAL NRKTSSKVAQ ATCKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325] PSI-BLAST 88.0 Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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