YRC Public Data Repository - Protein Structure Prediction

Protein:	HMGCL
Organism:	Homo sapiens
Length:	325 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMGCL.

Description	E-value	Query Range	Subject Range
gi\|114554638 - gi\|114554638\|ref\|XP_001166273.1\| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydro...	5.0E-93	[1..325]	[1..325]
HMGCL_MACFA - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Macaca fascicularis GN=HMGCL PE=2 SV=1	2.0E-92	[1..325]	[1..325]
gi\|184503, gi\|47... - pir\|\|A45470 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) - human, ref\|NP_000182.1\| 3-hydroxymethyl-3...	2.0E-92	[1..325]	[1..325]
HMGCL_PONAB - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Pongo abelii GN=HMGCL PE=2 SV=1 HMGCL_PONPY - Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor - Pongo pygmaeus (Orangutan)	2.0E-92	[1..325]	[1..325]
HMGCL_RAT - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Rattus norvegicus GN=Hmgcl PE=2 SV=1	2.0E-91	[1..325]	[1..325]
HMGCL_BOVIN - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Bos taurus GN=HMGCL PE=2 SV=2	6.0E-91	[1..325]	[1..325]
HMGCL_MOUSE - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Mus musculus GN=Hmgcl PE=1 SV=2	7.0E-91	[1..325]	[1..325]

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Predicted Domain #1

Region A:
Residues: [1-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI VSTPVKIKLI  60
   61 DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG INYPVLTPNL KGFEAAVAAG 120
  121 AKEVVIFGAA SELFTKKNIN CSIEESFQRF DAILKAAQSA NISVRGYVSC ALGCPYEGKI 180
  181 SPAKVAEVTK KFYSMGCYEI SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ 240
  241 ALANTLMALQ MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL 300
  301 EAGNFICQAL NRKTSSKVAQ ATCKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.0
Match:	2cw6A
Description:	Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits