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Protein Overview: PDE4D

General Information:
Name(s) found: PDE4D [HGNC (HUGO)]
Description(s) found:
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  • gi|2623739|gb|AAC00042.1| cyclic AMP phosphodiesterase [Homo sapiens] [NCBI NR]
  • gi|157277988|ref|NP_001098101.1| phosphodiesterase 4D isoform 1 [Homo sapiens] [NCBI NR]
  • gi|12644392|sp|Q08499.2|PDE4D_HUMAN RecName: Full=cAMP-specific 3',5'-cyclic phosphodiesterase 4D; AltName: Full=DPDE3; AltName: Full=PDE43 [NCBI NR]
  • gi|119575384|gb|EAW54989.1| phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), isoform CRA_h [Homo sapiens] [NCBI NR]
  • phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) [HGNC (HUGO)]
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Homo sapiens GN=PDE4D PE=1 SV=2 [Swiss-Prot]
  • (Q08499) cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43) [Swiss-Prot]
  • Splice isoform 1 of Q08499 [hmr_yeast5_DM3-1_pombe.fasta]
  • cyclic AMP phosphodiesterase [Homo sapiens]gi|12644392|sp|Q08499|CN4D_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4D (DPDE3) (PDE43) [nrdb_11152004_Chlamydomonas]
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D (DPDE3) (PDE43) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006203) phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); Phosphodiesterase-4D, cAMP-specific (dunce (Drosophila)-homolog; phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3) [Homo [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • cyclic AMP phosphodiesterase [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • cAMP-specific phosphodiesterase 4D isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), isoform CRA_h [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PDE4D Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [human-ipi-250309-contam.fasta]
  • phosphodiesterase 4D isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00002449.1|SWISS-PROT:Q08499-1|TREMBL:Q9HCX6|ENSEMBL:ENSP00000384806|REFSEQ:NP_001098101 Tax_Id=9606 Gene_Symbol=PDE4D Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PDE4D Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D ENSG00000113448 IPI00514643 IPI00002449 IPI00514112 IPI00478370 IPI00514183 IPI00386765 IPI00217565 IPI00217567 IPI00828158 IPI00375233 IPI00375235 IPI00375236 IPI00382487 [drosphohumanreversed.fasta]
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q08499;O43433;Q13549;Q13550;Q13551;Q7Z2L8;Q8IV84;Q8IVA9;Q8IVD2;Q8IVD3;Q96HL4;Q9HCX7; RecName: Full=cAMP-specific 3',5'-cyclic phosphodiesterase 4D; AltName: Full=DPDE3; AltName: Full=PDE43; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Homo sapiens GN=PDE4D [011711_HMR.fasta]
  • GeneSymbol=PDE4D Synonyms=DKFZp686M11213|DPDE3|FLJ97311|HSPDE4D|PDE4DN2|STRK1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Homo sapiens GN=PDE4D [122011_hum.fasta]
  • IPI:IPI00002449.1|SWISS-PROT:Q08499-1|TREMBL:Q9HCX6|ENSEMBL:ENSP00000345502|REFSEQ:NP_001098101|VEGA:OTTHUMP00000221595 Tax_Id=9606 Gene_Symbol=PDE4D Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [ipi.HUMAN.20110912.fasta]
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D GN=PDE4D [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=PDE4D Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D [human-ipi-270911-contam-BSA.fasta]
    • Organism: Homo sapiens
    Length: 809 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAEGSSAPA RAGSGEGSDS AGGATLKAPK HLWRHEQHHQ YPLRQPQFRL LHPHHHLPPP  60
   61 PPPSPQPQPQ CPLQPPPPPP LPPPPPPPGA ARGRYASSGA TGRVRHRGYS DTERYLYCRA 120
  121 MDRTSYAVET GHRPGLKKSR MSWPSSFQGL RRFDVDNGTS AGRSPLDPMT SPGSGLILQA 180
  181 NFVHSQRRES FLYRSDSDYD LSPKSMSRNS SIASDIHGDD LIVTPFAQVL ASLRTVRNNF 240
  241 AALTNLQDRA PSKRSPMCNQ PSINKATITE EAYQKLASET LEELDWCLDQ LETLQTRHSV 300
  301 SEMASNKFKR MLNRELTHLS EMSRSGNQVS EFISNTFLDK QHEVEIPSPT QKEKEKKKRP 360
  361 MSQISGVKKL MHSSSLTNSS IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL 420
  421 TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST 480
  481 PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF 540
  541 KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL 600
  601 LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC 660
  661 DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP 720
  721 DDPEEGRQGQ TEKFQFELTL EEDGESDTEK DSGSQVEEDT SCSDSKTLCT QDSESTEIPL 780
  781 DEQVEEEAVG EEEESQPEAC VIDDRSPDT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..256] PSI-BLAST 5.0 No description for 1y0fA was found.
    2 View Details [257..342] deduced N/A No confident structure predictions are available.
    3 View Details [343..809] PSI-BLAST 162.0 No description for 2fm0A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle