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View Structure Prediction Details

Protein: PDE4D
Organism: Homo sapiens
Length: 809 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDE4D.

Description E-value Query
Range
Subject
Range
gi|114600121 - gi|114600121|ref|XP_001138439.1| PREDICTED: similar to cyclic AMP phosphodiesterase isoform 6 [Pan t...
0.0 [1..809] [1..809]
PDE4D_RAT - cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Rattus norvegicus GN=Pde4d PE=1 SV=4
0.0 [1..809] [1..803]
gi|347130, gi|32... - gi|347130|gb|AAA03592.1| phosphodiesterase, gi|32306513|ref|NP_006194.2| phosphodiesterase 4D isofor...
0.0 [142..809] [6..673]

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Predicted Domain #1
Region A:
Residues: [1-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAEGSSAPA RAGSGEGSDS AGGATLKAPK HLWRHEQHHQ YPLRQPQFRL LHPHHHLPPP  60
   61 PPPSPQPQPQ CPLQPPPPPP LPPPPPPPGA ARGRYASSGA TGRVRHRGYS DTERYLYCRA 120
  121 MDRTSYAVET GHRPGLKKSR MSWPSSFQGL RRFDVDNGTS AGRSPLDPMT SPGSGLILQA 180
  181 NFVHSQRRES FLYRSDSDYD LSPKSMSRNS SIASDIHGDD LIVTPFAQVL ASLRTVRNNF 240
  241 AALTNLQDRA PSKRSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #2
Region A:
Residues: [257-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCNQPSINKA TITEEAYQKL ASETLEELDW CLDQLETLQT RHSVSEMASN KFKRMLNREL  60
   61 THLSEMSRSG NQVSEFISNT FLDKQH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [343-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVEIPSPTQK EKEKKKRPMS QISGVKKLMH SSSLTNSSIP RFGVKTEQED VLAKELEDVN  60
   61 KWGLHVFRIA ELSGNRPLTV IMHTIFQERD LLKTFKIPVD TLITYLMTLE DHYHADVAYH 120
  121 NNIHAADVVQ STHVLLSTPA LEAVFTDLEI LAAIFASAIH DVDHPGVSNQ FLINTNSELA 180
  181 LMYNDSSVLE NHHLAVGFKL LQEENCDIFQ NLTKKQRQSL RKMVIDIVLA TDMSKHMNLL 240
  241 ADLKTMVETK KVTSSGVLLL DNYSDRIQVL QNMVHCADLS NPTKPLQLYR QWTDRIMEEF 300
  301 FRQGDRERER GMEISPMCDK HNASVEKSQV GFIDYIVHPL WETWADLVHP DAQDILDTLE 360
  361 DNREWYQSTI PQSPSPAPDD PEEGRQGQTE KFQFELTLEE DGESDTEKDS GSQVEEDTSC 420
  421 SDSKTLCTQD SESTEIPLDE QVEEEAVGEE EESQPEACVI DDRSPDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 162.0
Match: 2fm0A
Description: No description for 2fm0A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle