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Protein Overview: gi|27436948

General Information:
Name(s) found: gi|27436948 [NCBI NR]
Description(s) found:
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  • gi|27436948|ref|NP_733822.1| lamin A/C isoform 3 [Homo sapiens] [NCBI NR]
  • Splice isoform ADelta10 of P02545 Lamin A/C [hmr_yeast5_DM3-1_pombe.fasta]
  • lamin A/C isoform 3; 70 kDa lamin; Charcot-Marie-Tooth disease, axonal, type 2B1; progeria 1 (Hutchinson-Gilford type) [HMR_022704.fasta]
  • lamin A/C isoform 3; 70 kDa lamin; progeria 1 (Hutchinson-Gilford type); Charcot-Marie-Tooth disease, axonal, type 2B1 [071204_hmrz_cont.fasta]
  • lamin A/C isoform 3 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform ADelta10 of Lamin-A/C [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform ADelta10 of Lamin A/C [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • lamin A/C isoform 3; 70 kDa lamin; progeria 1 (Hutchinson-Gilford type); Charcot-Marie-Tooth disease, axonal, type 2B1 [Homo sapiens] [HumanGallus06162005.fasta]
  • lamin A/C isoform 3; 70 kDa lamin; Charcot-Marie-Tooth disease, axonal, type 2B1; progeria 1 (Hutchinson-Gilford type) [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Tax_Id=9606 Isoform ADelta10 of Lamin-A/C [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 3 OF LAMIN A/C [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LMNA Isoform ADelta10 of Lamin-A/C [human-ipi-250309-contam.fasta]
  • IPI:IPI00216953.1|SWISS-PROT:P02545-3|ENSEMBL:ENSP00000292304|REFSEQ:NP_733822 Tax_Id=9606 Gene_Symbol=LMNA Isoform ADelta10 of Lamin-A/C [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • lamin-A/C isoform 3 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Isoform ADelta10 of Prelamin-A/C OS=Homo sapiens GN=LMNA [011711_HMR.fasta]
  • GeneSymbol=LMNA Synonyms=CDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|PRO1 prelamin-A/C isoform 3 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00216953.1|SWISS-PROT:P02545-3|ENSEMBL:ENSP00000292304;ENSP00000424977|REFSEQ:NP_733822|VEGA:OTTHUMP00000217836 Tax_Id=9606 Gene_Symbol=LMNA Isoform ADelta10 of Prelamin-A/C [ipi.HUMAN.20110912.fasta]
  • Isoform ADelta10 of Prelamin-A/C GN=LMNA [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=LMNA Isoform ADelta10 of Prelamin-A/C [human-ipi-270911-contam-BSA.fasta]
  • Isoform of P02545, Isoform ADelta10 of Prelamin-A/C OS=Homo sapiens GN=LMNA [2016-04-human-contam-aPKC-His-Par6.fasta]
    • Organism: Homo sapiens
    Length: 634 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR  60
   61 LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN 120
  121 TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK 180
  181 KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR 240
  241 LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID 300
  301 SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ 360
  361 ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK 420
  421 LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT 480
  481 YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEGSHC 540
  541 SSSGDPAEYN LRSRTVLCGT CGQPADKASA SGSGAQVGGP ISSGSSASSV TVTRSYRSVG 600
  601 GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN CSIM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CENPA No Comments Foltz DR, et al (2006)
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)
    View Run None Entered Sample pIC146 from april 2005 Okada, M., et al. (2006)
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 7.69897 Tropomyosin
    2 View Details [87..307] FFAS03 2.08 No description for 2i1jA was found.
    3 View Details [308..389] PSI-BLAST 3.09691 Human lamin coil 2B
    4 View Details [390..463] FFAS03 2.49 Solution structure of immunoglobulin like domain of mouse nuclear lamin
    5 View Details [464..541] PSI-BLAST 16.69897 Solution structure of immunoglobulin like domain of mouse nuclear lamin
    6 View Details [542..634] MSA 1.103987 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle