Protein Overview: NPC1

General Information:
Name(s) found:	NPC1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	sp\|O15118\|NPC1_HUMAN Niemann-Pick C1 protein precursor [NCBI NR] gi\|5714634\|gb\|AAD48006.1\| Niemann-Pick C1 protein [Homo sapiens] [NCBI NR] gi\|4557803\|ref\|NP_000262.1\| Niemann-Pick disease, type C1 precursor [Homo sapiens] [NCBI NR] gi\|2276463\|gb\|AAB63982.1\| Niemann-Pick C disease protein [Homo sapiens] [NCBI NR] gi\|13430254\|gb\|AAK25791.1\|AF338230_1 Niemann-Pick disease C1 protein [Homo sapiens] [NCBI NR] gi\|119621563\|gb\|EAX01158.1\| Niemann-Pick disease, type C1 [Homo sapiens] [NCBI NR] Niemann-Pick disease, type C1 [HGNC (HUGO)] (O15118) Niemann-Pick C1 protein precursor [Swiss-Prot] Niemann-Pick C1 protein precursor [hmr_yeast5_DM3-1_pombe.fasta] Niemann-Pick disease, type C1 [Homo sapiens]gi\|8134594\|sp\|O15118\|NPC1_HUMAN Niemann-Pick C1 protein precursorgi\|5714634\|gb\|AAD48006.1\| Niemann-Pick C1 protein [Homo sapiens]gi\|13430254\|gb\|AAK25791.1\| Niemann-Pick disease C1 protein [Homo sapiens]gi\|22 [nrdb_11152004_Chlamydomonas] (NM_000271) Niemann-Pick disease, type C1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Niemann-Pick disease, type C1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Tax_Id=9606 Niemann-Pick C1 protein precursor [EBI-IPI_human_3.04_03-07-2005_reverse.fasta] Niemann-Pick disease, type C1 precursor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Niemann-Pick disease C1 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Niemann-Pick C1 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Niemann-Pick C disease protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 NIEMANN-PICK C1 PROTEIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Niemann-Pick C1 protein OS=Homo sapiens GN=NPC1 PE=1 SV=2 VAR_008823 [swiss.HUMAN.20141123.contam.amyloid.poly.fasta]
Organism:	Homo sapiens
Length:	1278 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTARGLALGL LLLLLCPAQV FSQSCVWYGE CGIAYGDKRY NCEYSGPPKP LPKDGYDLVQ  60
   61 ELCPGFFFGN VSLCCDVRQL QTLKDNLQLP LQFLSRCPSC FYNLLNLFCE LTCSPRQSQF 120
  121 LNVTATEDYV DPVTNQTKTN VKELQYYVGQ SFANAMYNAC RDVEAPSSND KALGLLCGKD 180
  181 ADACNATNWI EYMFNKDNGQ APFTITPVFS DFPVHGMEPM NNATKGCDES VDEVTAPCSC 240
  241 QDCSIVCGPK PQPPPPPAPW TILGLDAMYV IMWITYMAFL LVFFGAFFAV WCYRKRYFVS 300
  301 EYTPIDSNIA FSVNASDKGE ASCCDPVSAA FEGCLRRLFT RWGSFCVRNP GCVIFFSLVF 360
  361 ITACSSGLVF VRVTTNPVDL WSAPSSQARL EKEYFDQHFG PFFRTEQLII RAPLTDKHIY 420
  421 QPYPSGADVP FGPPLDIQIL HQVLDLQIAI ENITASYDNE TVTLQDICLA PLSPYNTNCT 480
  481 ILSVLNYFQN SHSVLDHKKG DDFFVYADYH THFLYCVRAP ASLNDTSLLH DPCLGTFGGP 540
  541 VFPWLVLGGY DDQNYNNATA LVITFPVNNY YNDTEKLQRA QAWEKEFINF VKNYKNPNLT 600
  601 ISFTAERSIE DELNRESDSD VFTVVISYAI MFLYISLALG HIKSCRRLLV DSKVSLGIAG 660
  661 ILIVLSSVAC SLGVFSYIGL PLTLIVIEVI PFLVLAVGVD NIFILVQAYQ RDERLQGETL 720
  721 DQQLGRVLGE VAPSMFLSSF SETVAFFLGA LSVMPAVHTF SLFAGLAVFI DFLLQITCFV 780
  781 SLLGLDIKRQ EKNRLDIFCC VRGAEDGTSV QASESCLFRF FKNSYSPLLL KDWMRPIVIA 840
  841 IFVGVLSFSI AVLNKVDIGL DQSLSMPDDS YMVDYFKSIS QYLHAGPPVY FVLEEGHDYT 900
  901 SSKGQNMVCG GMGCNNDSLV QQIFNAAQLD NYTRIGFAPS SWIDDYFDWV KPQSSCCRVD 960
  961 NITDQFCNAS VVDPACVRCR PLTPEGKQRP QGGDFMRFLP MFLSDNPNPK CGKGGHAAYS1020
 1021 SAVNILLGHG TRVGATYFMT YHTVLQTSAD FIDALKKARL IASNVTETMG INGSAYRVFP1080
 1081 YSVFYVFYEQ YLTIIDDTIF NLGVSLGAIF LVTMVLLGCE LWSAVIMCAT IAMVLVNMFG1140
 1141 VMWLWGISLN AVSLVNLVMS CGISVEFCSH ITRAFTVSMK GSRVERAEEA LAHMGSSVFS1200
 1201 GITLTKFGGI VVLAFAKSQI FQIFYFRMYL AMVLLGATHG LIFLPVLLSY IGPSVNKAKS1260
 1261 CATEERYKGT ERERLLNF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NPC1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: