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Protein Overview: DAM1

General Information:
Name(s) found: DAM1 / YGR113W [SGD]
Description(s) found:
Found 8 descriptions.
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  • Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 335 amino acids

    Gene Ontology:
    Cellular Component: spindle midzone [IDALink to PubMed article]
    kinetochore microtubule [IDALink to PubMed article]
    DASH complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    spindle [IPILink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: mitotic spindle organization in nucleus [IGILink to PubMed article]
    regulation of microtubule polymerization or depolymerization [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEDKAKLGT TRSATEYRLS IGSAPTSRRS SMGESSSLMK FADQEGLTSS VGEYNENTIQ  60
   61 QLLLPKIREL SDSIITLDSN FTRLNFIHES LADLNESLGS LLYGIMSNSW CVEFSQAPHD 120
  121 IQDDLIAIKQ LKSLEDEKNN LVMELSNMER GIKRKKDEQG ENDLAKASQN KQFNQPLFPS 180
  181 SQVRKYRSYD NRDKRKPSKI GNNLQVENEE DYEDDTSSEA SFVLNPTNIG MSKSSQGHVT 240
  241 KTTRLNNNTN SKLRRKSILH TIRNSIASGA DLPIENDNVV NLGDLHPNNR IYSEVVLQEW 300
  301 SMGPLRRTEI QCSQDVLKGN PQKADILLQR KLKKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle