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Protein Overview: MSC2

General Information:
Name(s) found: MSC2 / YDR205W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: cellular zinc ion homeostasis [IMPLink to PubMed article]
    Molecular Function: cation:cation antiporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL IFFSTDHAIR  60
   61 LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL SILTAIFHPI QSTCITLLII 120
  121 KLLTTADESS PKIALNFKTI LKTFVPFITL TLVILRWDPS FDASSGDVNK ISTSLAAYAL 180
  181 LILTLRYASP LILSTLSSSI GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV 240
  241 NKTYNIQLLM VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT 300
  301 RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP DSHSHNHAHH 360
  361 HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF VQLLYSFRSK SLGLLSDSLH 420
  421 MALDCTSLLL GLIAGVLTKK PASDKFPFGL NYLGTLAGFT NGVLLLGIVC GIFVEAIERI 480
  481 FNPIHLHATN ELLVVATLGL LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV 540
  541 GVVISTLLIK LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL 600
  601 NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG SQEHPSLVGY 660
  661 IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC WCRATSMNTI SANPNSLPLQ 720
  721 PIAN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YDR131C MSC2 1 Unpublished Fields Lab Data
    View Screen NAF1 MSC2 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] deduced N/A No confident structure predictions are available.
    2 View Details [283..372] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [373..502] MSA 6.423993 View MSA. No confident structure predictions are available.
    4 View Details [503..724] MSA 20.40399 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transporter activity
    		•  4.27173462293249 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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