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Protein Overview: ISR1

General Information:
Name(s) found: ISR1 / YPR106W [SGD]
Description(s) found:
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  • gi|914977|gb|AAB68076.1| Ypr106wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74676378|sp|Q06098.1|ISR1_YEAST RecName: Full=Serine/threonine-protein kinase ISR1; AltName: Full=Inhibition of staurosporine resistance protein 1 [NCBI NR]
  • gi|6325363|ref|NP_015431.1| Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C; Isr1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59771 hypothetical protein YPR106w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Serine/threonine-protein kinase ISR1 OS=Saccharomyces cerevisiae GN=ISR1 PE=1 SV=1 [Swiss-Prot]
  • ISR1 Protein kinase [mips]
  • Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C [SGD]
  • >Q06098 (Q06098) Similar to protein kinases GCN2 [4932.FASTACCERV.txt]
  • Chr XVI from 740057-741388 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 740058-741389 [yeastorf3.fasta]
  • ISR1, Chr XVI from 740058-741389 [yeast_orfs2]
  • ISR1 SGDID:S0006310, Chr XVI from 740057-741388, Verified ORF [yeastflysequest.fasta]
  • ISR1 SGDID:S0006310, Chr XVI from 740059-741390, Verified ORF [10112005cervSGD.fasta]
  • Isr1p [Saccharomyces cerevisiae]gi|914977|gb|AAB68076.1| Ypr106wp [Saccharomyces cerevisiae]gi|2132283|pir||S59771 hypothetical protein YPR106w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q06098) Ypr106wp [cerv4932.FASTAC]
  • ISR1 SGDID:S000006310, Chr XVI from 740059-741390, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Serine/threonine-protein kinase ISR1 (Inhibition of staurosporine resistance protein 1) [nr-271106-contam.fasta]
  • Ypr106wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C; Isr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein kinase ISR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C" [yeast-030211-contam.fasta]
  • ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-2-1, Verified ORF, "Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C" [20141208_orf_trans.fasta]
  • YPR106W SGDID:S000006310, Chr XVI from 740061-741392, Genome Release 64-1-1, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTPPTSPV TRVSDGSFPS ISNNSKGFAY RQPQKHKSNF AYSHLVSPVE EPTAKFSEAF  60
   61 QTDYSSKAPV ATSEAHLKND LDVLFTTPRF YSPENLALMF RLSNTVSSLE FLDEFLMGIL 120
  121 LAPEMDFLSN PSYSLPSNKL VGQGSYSYVY PISSSASSRC NNDSGVVLKF AKSQHKSKVI 180
  181 LQEALTLAYL QYMSPSTNES HIIPFYGLTY ITKSHFRRLR SNECVPGLIL PKCEMSLYHF 240
  241 NTAVSHKLSL ITKRKIWWRL MKQMIDALKS LKTNGIIHGD IKTANILITE MHVLNGGHCK 300
  301 DFDFYLADFT SAFHINQTPT DLNTTVEYCA PELIDSSSDH VPTFESDLYA VGLCLLSFIS 360
  361 QHEPYNELQA LVSHGSSPGI GSSSIQQSQW LINALLKKDP INLNMLRNDL FQDWKSELAL 420
  421 LSRILVDRLP LENLITILDS NYI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ISR1 NCR1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..232] PSI-BLAST 108.0 pak1
    3 View Details [233..443] PSI-BLAST 108.0 pak1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle