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View Structure Prediction Details

Protein: ISR1
Organism: Saccharomyces cerevisiae
Length: 443 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISR1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [9..433] [121..538]
gi|7677056 - gi|7677056|gb|AAF67008.1|AF155651_1 P21-activated kinase 3 [Homo sapiens]
0.0 [9..435] [131..539]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
0.0 [9..433] [121..538]
gi|5679324, gi|1... - gi|5679324|gb|AAD46921.1|AF169794_1 p21 GTPase-associated kinase 1 [Xenopus laevis], gi|148232670|re...
0.0 [9..434] [112..522]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTPPTSPV TRVSDGSFPS ISNNSKGFAY RQPQKHKSNF AYSHLVSPVE EPTAKFSEAF  60
   61 QTDYSSKAPV ATSEAH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNDLDVLFT TPRFYSPENL ALMFRLSNTV SSLEFLDEFL MGILLAPEMD FLSNPSYSLP  60
   61 SNKLVGQGSY SYVYPISSSA SSRCNNDSGV VLKFAKSQHK SKVILQEALT LAYLQYMSPS 120
  121 TNESHIIPFY GLTYITKSHF RRLRSNECVP GLILPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEMSLYHFNT AVSHKLSLIT KRKIWWRLMK QMIDALKSLK TNGIIHGDIK TANILITEMH  60
   61 VLNGGHCKDF DFYLADFTSA FHINQTPTDL NTTVEYCAPE LIDSSSDHVP TFESDLYAVG 120
  121 LCLLSFISQH EPYNELQALV SHGSSPGIGS SSIQQSQWLI NALLKKDPIN LNMLRNDLFQ 180
  181 DWKSELALLS RILVDRLPLE NLITILDSNY I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle