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View Structure Prediction Details

Protein: ISR1
Organism: Saccharomyces cerevisiae
Length: 443 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISR1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [9..433] [121..538]
gi|7677056 - gi|7677056|gb|AAF67008.1|AF155651_1 P21-activated kinase 3 [Homo sapiens]
0.0 [9..435] [131..539]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
0.0 [9..433] [121..538]
gi|5679324, gi|1... - gi|5679324|gb|AAD46921.1|AF169794_1 p21 GTPase-associated kinase 1 [Xenopus laevis], gi|148232670|re...
0.0 [9..434] [112..522]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTPPTSPV TRVSDGSFPS ISNNSKGFAY RQPQKHKSNF AYSHLVSPVE EPTAKFSEAF  60
   61 QTDYSSKAPV ATSEAH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.475 a.4.5 "Winged helix" DNA-binding domain
View Download 0.503 a.61.1 Retroviral matrix proteins
View Download 0.626 a.60.2 RuvA domain 2-like
View Download 0.455 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.626 a.60.2 RuvA domain 2-like
View Download 0.574 a.60.11 Hypothetical protein YjbJ
View Download 0.574 a.60.11 Hypothetical protein YjbJ
View Download 0.503 a.61.1 Retroviral matrix proteins
View Download 0.475 a.4.5 "Winged helix" DNA-binding domain
View Download 0.455 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.455 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.445 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.381 a.118.8 TPR-like
View Download 0.379 a.60.1 SAM/Pointed domain
View Download 0.357 a.3.1 Cytochrome c
View Download 0.341 a.49.1 C-terminal domain of B transposition protein
View Download 0.334 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.324 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.323 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.320 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.290 a.39.1 EF-hand
View Download 0.271 a.17.1 p8-MTCP1
View Download 0.255 a.4.1 Homeodomain-like
View Download 0.241 d.8.1 Urease, gamma-subunit
View Download 0.223 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.221 a.24.11 Bacterial GAP domain

Predicted Domain #2
Region A:
Residues: [77-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNDLDVLFT TPRFYSPENL ALMFRLSNTV SSLEFLDEFL MGILLAPEMD FLSNPSYSLP  60
   61 SNKLVGQGSY SYVYPISSSA SSRCNNDSGV VLKFAKSQHK SKVILQEALT LAYLQYMSPS 120
  121 TNESHIIPFY GLTYITKSHF RRLRSNECVP GLILPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEMSLYHFNT AVSHKLSLIT KRKIWWRLMK QMIDALKSLK TNGIIHGDIK TANILITEMH  60
   61 VLNGGHCKDF DFYLADFTSA FHINQTPTDL NTTVEYCAPE LIDSSSDHVP TFESDLYAVG 120
  121 LCLLSFISQH EPYNELQALV SHGSSPGIGS SSIQQSQWLI NALLKKDPIN LNMLRNDLFQ 180
  181 DWKSELALLS RILVDRLPLE NLITILDSNY I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle