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Protein Overview: TAH18

General Information:
Name(s) found: TAH18 / YPR048W [SGD]
Description(s) found:
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  • gi|805031|emb|CAA89168.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74583816|sp|Q12181.1|TAH18_YEAST RecName: Full=Probable NADPH reductase TAH18 [NCBI NR]
  • gi|6325305|ref|NP_015373.1| Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta; Tah18p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1314119|emb|CAA94995.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S54072 probable membrane protein YPR048w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Probable NADPH reductase TAH18 OS=Saccharomyces cerevisiae GN=TAH18 PE=1 SV=1 [Swiss-Prot]
  • TAH18 Protein with a potential role in DNA replication [mips]
  • Protein of unknown function that plays a pro-death role in response to oxidative stress; highly conserved across species and similar to human protein NDOR1; allele is synthetically lethal with the pol3-13 allele of DNA polymerase delta [SGD]
  • >Q12181 (Q12181) TAH18 protein [4932.FASTACCERV.txt]
  • Chr XVI from 659177-661048 [hmr_yeast5_DM3-1_pombe.fasta]
  • TAH18, Chr XVI from 659177-661048 [yeast_orfs2]
  • TAH18 SGDID:S0006252, Chr XVI from 659177-661048, Verified ORF [yeastflysequest.fasta]
  • TAH18 SGDID:S0006252, Chr XVI from 659179-661050, Verified ORF [10112005cervSGD.fasta]
  • Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta [Saccharomyces cerevisiae]gi|805031|emb|CAA89168.1| unknown [Saccharomyces cerevisiae]gi| [nrdb_11152004_Chlamydomonas]
  • (Q12181) Hypothetical protein YPR044W [cerv4932.FASTAC]
  • TAH18 SGDID:S000006252, Chr XVI from 659179-661050, Verified ORF, "Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659179-661050, Verified ORF, "Protein of unknown function; highly conserved across species and similar to human protein NDOR1; null mutant is inviable; allele is synthetically lethal with the pol3-13 allele of DNA poly [yeast-200209-contam.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659179-661050, Verified ORF, "Protein of unknown function that plays a pro-death role in response to oxidative stress; highly conserved across species and similar to human protein NDOR1; allele is synthetically lethal [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta]
  • Probable NADPH reductase TAH18 [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta; Tah18p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659179-661050, Verified ORF, "Protein of unknown function; highly conserved across species and similar to human protein NDOR1; null mutant is inviable; allele is synthetically lethal with the pol3-13 allele of DNA polymerase delta" [yeast-bovrabprots.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659179-661050, Verified ORF, "Protein of unknown function that plays a pro-death role in response to oxidative stress; highly conserved across species and similar to human protein NDOR1; allele is synthetically lethal with the pol3-13 allele of DNA polymerase delta" [scerevisihumanrev.fasta]
  • [chemostatdb.fasta]
  • Probable NADPH reductase TAH18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAH18 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659182-661053, Genome Release 64-1-1, Verified ORF, "Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress" [yeast-030211-contam.fasta]
  • TAH18 SGDID:S000006252, Chr XVI from 659182-661053, Genome Release 64-2-1, Verified ORF, "Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs" [20141208_orf_trans.fasta]
  • YPR048W SGDID:S000006252, Chr XVI from 659182-661053, Genome Release 64-1-1, Verified ORF, "Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 623 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSKKIVIL YGSETGNAHD FATILSHRLH RWHFSHTFCS IGDYDPQDIL KCRYLFIICS  60
   61 TTGQGELPRN VNALKGERPV TFWSFLKRKN LPSNLLNHIQ TAMLGLGDSS YPKFNYGIRK 120
  121 LHQRIVTQLG ANELFDRLEA DDQAMAGSNK GTGLGIESVY FEYEKKVLSF LLSKYPNRKV 180
  181 NGQIIKREEL DPEVYLEPAS YLQLSDEHAN EKFTSTKVIF EGDESLKVGR VNINKRITSE 240
  241 GHFQDVRQFK FSNVDKIQEN YEPGDTVTIY PCNTDEDVSR FLANQSHWLE IADKPLNFTS 300
  301 GVPNDLKDGG LVRPMTLRNL LKYHCDFMSI PRTSFFLKIW TFATDVTKME RGQEQLNDQR 360
  361 EKLRQFATDQ DMQDLYDYCN RPRRSILEVL EDFISVKLPW KYVLDYLPII KPRYYSISSG 420
  421 PGDPNIELTV AIVKYKTILR KIRRGICTNY IARLQEGEQI RYKLQNNHII KKEFLNKPMI 480
  481 LVGPGVGLAP LLSVVKAEIS KDIKLLFGCR YKDKDYIYKD MLEDWFRKGK IALHSSFSRD 540
  541 EENSPGVKYV QDYLWRLGEE ITNLVVNKDA VFFLCGSSGK MPIQVRLTFI EMLKKWGNFS 600
  601 DEETAKKYLK EMEKSDRYIQ ETW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DRE2 SES1 TAH18

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 1373.9794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    2 View Details [188..212]
    [272..411]
    [434..445]    		 PSI-BLAST 1373.9794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    3 View Details [213..271]
    [412..433]
    [446..467]    		 PSI-BLAST 1373.9794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    4 View Details [468..623] PSI-BLAST 1373.9794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle