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Protein Overview: ICL2

General Information:
Name(s) found: ICL2 / YPR006C [SGD]
Description(s) found:
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  • gi|939740|gb|AAA97585.1| Lpz6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|763005|emb|CAA88784.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6325263|ref|NP_015331.1| 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by et [NCBI NR]
  • gi|2497268|sp|Q12031.1|ACEB_YEAST RecName: Full=Mitochondrial 2-methylisocitrate lyase; Short=Methylisocitrate lyase [NCBI NR]
  • gi|1314081|emb|CAA95046.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S52819 isocitrate lyase (EC 4.1.3.1) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae GN=ICL2 PE=1 SV=1 [Swiss-Prot]
  • ICL2 Non-functional isocitrate lyase [mips]
  • 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol [SGD]
  • (Q12031) Inactive isocitrate lyase [4932.FASTACCERV.txt]
  • Chr XVI from 568991-567264, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 567264-568991, reverse complement [yeastorf3.fasta]
  • ICL2, Chr XVI from 567264-568991, reverse complement [yeast_orfs2]
  • ICL2 SGDID:S0006210, Chr XVI from 568991-567264, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ICL2 SGDID:S0006210, Chr XVI from 568993-567266, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol [Saccharomyces cerevis [nrdb_11152004_Chlamydomonas]
  • ICL2 SGDID:S000006210, Chr XVI from 568993-567266, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; IC [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mitochondrial 2-methylisocitrate lyase (Methylisocitrate lyase) [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol; Icl2p [Saccharomyces [nr-271106-contam.fasta]
  • Lpz6p [nr-271106-contam.fasta]
  • ICL2 SGDID:S000006210, Chr XVI from 568993-567266, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ICL2 SGDID:S000006210, Chr XVI from 568996-567269, Genome Release 64-1-1, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" [yeast-030211-contam.fasta]
  • ICL2 SGDID:S000006210, Chr XVI from 568996-567269, Genome Release 64-2-1, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" [20141208_orf_trans.fasta]
  • YPR006C SGDID:S000006210, Chr XVI from 568996-567269, Genome Release 64-1-1, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: propionate metabolic process [IDALink to PubMed article][IEPLink to PubMed article]
    threonine catabolic process [IEPLink to PubMed article]
    Molecular Function: methylisocitrate lyase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITMINNKTF NRKTTGTLKK LVLSSDKSLR RSFNGASSTK DFVFSESSKV EEWWESARFK  60
   61 NISRPYSATD VVKHRGSLPA NTSIYPSSYQ ARKLFNLLEE NFKNGTPLHT LGVIDPVQMS 120
  121 QLARCRNIKV AYISGWACSS TLVGSTNEVS PDFGDYPYDT VPNQVERIFK AQQLHDRKAF 180
  181 LEASIKGSTP VDYLKPIIAD ADMGHGGPTT VMKVAKLFAE KGAAGIHLED QMVGGKRCGH 240
  241 LSGAVLVPTA THLMRLISTR FQWDIMGTEN LVIARTDSCN GKLLSSSSDP RDHEFIRGII 300
  301 RDNVVPWSEK LIEMEDKKIP NSAIADMEKE WYHENELFTF EEALEKQFTA SEFESYKEKK 360
  361 EDLMVNKLGR AYLSLREMKL LAQEVTPLKK IIFDWDAPRT KEGYYMFNGC IEAAIRRSLV 420
  421 FAPYSDMIWL ETKTPDLEQA RSFSRKIHKQ LPATKLVYNL SPSFNWSAHG FDDKALKSFV 480
  481 WDLAKEGFTL QLVSLAGLHS DGVSFWELAN SFQSDGMKAY VEKVQKREKE TNCDIMTHQL 540
  541 WSGAEYVDSL MKVVQNGASS QTLSTSGESF TETQF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ACO1 FUM1 ICL2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ICL2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291]
    [407..575]    		 PSI-BLAST 2180.0 Isocitrate lyase
    2 View Details [292..406] PSI-BLAST 2180.0 Isocitrate lyase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methylisocitrate lyase activity
    		•  4.21728284668468 bayes_pls_golite062009
  • catalytic activity
    		•  2.59838799615646 bayes_pls_golite062009
  • isocitrate lyase activity
    		•  2.04609854331886 bayes_pls_golite062009
  • transferase activity
    		•  1.07154136609184 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
    		•  0.987472653142222 bayes_pls_golite062009
  • citrate (pro-3S)-lyase activity
    		•  0.38709069423063 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.366715189574293 bayes_pls_golite062009
  • lyase activity
    		•  0.0456521871650777 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle