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View Structure Prediction Details

Protein: ICL2
Organism: Saccharomyces cerevisiae
Length: 575 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ICL2.

Description E-value Query
Range		 Subject
Range
ACEA_CUCMA - Isocitrate lyase OS=Cucurbita maxima PE=2 SV=1
gi|1695645 - gi|1695645|dbj|BAA11320.1| Isocitrate Lyase [Cucurbita cv. Kurokawa Amakuri]
 0.0 [31..575] [6..551]
ACEA_GOSHI - Isocitrate lyase OS=Gossypium hirsutum PE=2 SV=1
 0.0 [31..575] [6..551]
ACEA_SOLLC - Isocitrate lyase OS=Solanum lycopersicum PE=2 SV=1
 0.0 [31..575] [6..551]
gi|12005499 - gi|12005499|gb|AAG44479.1|AF243525_1 isocitrate lyase [Ipomoea batatas]
 0.0 [32..575] [7..551]
gi|68210 - pir||WZCSI isocitrate lyase (EC 4.1.3.1) - castor bean
ACEA_RICCO - Isocitrate lyase OS=Ricinus communis PE=2 SV=1
 0.0 [31..575] [6..551]
ACEB_YEAST - Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=I...
ICL2 - 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to cataly...
 0.0 [1..575] [1..575]
ACEA_CUCSA - Isocitrate lyase OS=Cucumis sativus PE=3 SV=1
 0.0 [31..575] [6..551]
ACEA_BRANA - Isocitrate lyase OS=Brassica napus PE=2 SV=1
 0.0 [31..575] [6..551]
ACEA_ARATH - Isocitrate lyase OS=Arabidopsis thaliana GN=ICL PE=1 SV=2
 0.0 [31..575] [6..551]
ACEA_EMENI - Isocitrate lyase OS=Emericella nidulans GN=acuD PE=1 SV=3
ACEA_EMENI - Isocitrate lyase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)...
 0.0 [36..575] [4..536]

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Predicted Domain #1
Region A:
Residues: [1-291] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITMINNKTF NRKTTGTLKK LVLSSDKSLR RSFNGASSTK DFVFSESSKV EEWWESARFK  60
   61 NISRPYSATD VVKHRGSLPA NTSIYPSSYQ ARKLFNLLEE NFKNGTPLHT LGVIDPVQMS 120
  121 QLARCRNIKV AYISGWACSS TLVGSTNEVS PDFGDYPYDT VPNQVERIFK AQQLHDRKAF 180
  181 LEASIKGSTP VDYLKPIIAD ADMGHGGPTT VMKVAKLFAE KGAAGIHLED QMVGGKRCGH 240
  241 LSGAVLVPTA THLMRLISTR FQWDIMGTEN LVIARTDSCN GKLLSSSSDP R

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [407-575] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNGCIEAAIR RSLVFAPYSD MIWLETKTPD LEQARSFSRK IHKQLPATKL VYNLSPSFNW  60
   61 SAHGFDDKAL KSFVWDLAKE GFTLQLVSLA GLHSDGVSFW ELANSFQSDG MKAYVEKVQK 120
  121 REKETNCDIM THQLWSGAEY VDSLMKVVQN GASSQTLSTS GESFTETQF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2180.0
Match: 1dquA_
Description: Isocitrate lyase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methylisocitrate lyase activity 4.21728284668468 bayes_pls_golite062009
catalytic activity 2.59838799615646 bayes_pls_golite062009
isocitrate lyase activity 2.04609854331886 bayes_pls_golite062009
transferase activity 1.07154136609184 bayes_pls_golite062009
3-methyl-2-oxobutanoate hydroxymethyltransferase activity 0.987472653142222 bayes_pls_golite062009
citrate (pro-3S)-lyase activity 0.38709069423063 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.366715189574293 bayes_pls_golite062009
lyase activity 0.0456521871650777 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [292-406] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHEFIRGIIR DNVVPWSEKL IEMEDKKIPN SAIADMEKEW YHENELFTFE EALEKQFTAS  60
   61 EFESYKEKKE DLMVNKLGRA YLSLREMKLL AQEVTPLKKI IFDWDAPRTK EGYYM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2180.0
Match: 1dquA_
Description: Isocitrate lyase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle