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Protein Overview: ACEB_YEAST

General Information:
Name(s) found: ACEB_YEAST [Swiss-Prot]
Description(s) found:
  • Mitochondrial 2-methylisocitrate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICL2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITMINNKTF NRKTTGTLKK LVLSSDKSLR RSFNGASSTK DFVFSESSKV EEWWESARFK  60
   61 NISRPYSATD VVKHRGSLPA NTSIYPSSYQ ARKLFNLLEE NFKNGTPLHT LGVIDPVQMS 120
  121 QLARCRNIKV AYISGWACSS TLVGSTNEVS PDFGDYPYDT VPNQVERIFK AQQLHDRKAF 180
  181 LEASIKGSTP VDYLKPIIAD ADMGHGGPTT VMKVAKLFAE KGAAGIHLED QMVGGKRCGH 240
  241 LSGAVLVPTA THLMRLISTR FQWDIMGTEN LVIARTDSCN GKLLSSSSDP RDHEFIRGII 300
  301 RDNVVPWSEK LIEMEDKKIP NSAIADMEKE WYHENELFTF EEALEKQFTA SEFESYKEKK 360
  361 EDLMVNKLGR AYLSLREMKL LAQEVTPLKK IIFDWDAPRT KEGYYMFNGC IEAAIRRSLV 420
  421 FAPYSDMIWL ETKTPDLEQA RSFSRKIHKQ LPATKLVYNL SPSFNWSAHG FDDKALKSFV 480
  481 WDLAKEGFTL QLVSLAGLHS DGVSFWELAN SFQSDGMKAY VEKVQKREKE TNCDIMTHQL 540
  541 WSGAEYVDSL MKVVQNGASS QTLSTSGESF TETQF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291]
    [407..575]    		 PSI-BLAST 2180.0 Isocitrate lyase
    2 View Details [292..406] PSI-BLAST 2180.0 Isocitrate lyase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methylisocitrate lyase activity
    		•  4.21728284668468 bayes_pls_golite062009
  • catalytic activity
    		•  2.59838799615646 bayes_pls_golite062009
  • isocitrate lyase activity
    		•  2.04609854331886 bayes_pls_golite062009
  • transferase activity
    		•  1.07154136609184 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
    		•  0.987472653142222 bayes_pls_golite062009
  • citrate (pro-3S)-lyase activity
    		•  0.38709069423063 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.366715189574293 bayes_pls_golite062009
  • lyase activity
    		•  0.0456521871650777 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle