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Protein Overview: MDL2

General Information:
Name(s) found: MDL2 / YPL270W [SGD]
Description(s) found:
Found 12 descriptions.
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  • Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 820 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: aerobic respiration [IMPLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of substances [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTYVLLYGK LIMTTMILNT GRFEEWYKVC IIALKEKEIY VPSSPIAMLN GRLPLLRLGI  60
   61 CRNMLSRPRL AKLPSIRFRS LVTPSSSQLI PLSRLCLRSP AVGKSLILQS FRCNSSKTVP 120
  121 ETSLPSASPI SKGSARSAHA KEQSKTDDYK DIIRLFMLAK RDWKLLLTAI LLLTISCSIG 180
  181 MSIPKVIGIV LDTLKTSSGS DFFDLKIPIF SLPLYEFLSF FTVALLIGCA ANFGRFILLR 240
  241 ILSERVVARL RANVIKKTLH QDAEFFDNHK VGDLISRLGS DAYVVSRSMT QKVSDGVKAL 300
  301 ICGVVGVGMM CSLSPQLSIL LLFFTPPVLF SASVFGKQIR NTSKDLQEAT GQLTRVAEEQ 360
  361 LSGIKTVQSF VAEGNELSRY NVAIRDIFQV GKTAAFTNAK FFTTTSLLGD LSFLTVLAYG 420
  421 SYLVLQSQLS IGDLTAFMLY TEYTGNAVFG LSTFYSEIMQ GAGAASRLFE LTDRKPSISP 480
  481 TVGHKYKPDR GVIEFKDVSF SYPTRPSVQI FKNLNFKIAP GSSVCIVGPS GRGKSTIALL 540
  541 LLRYYNPTTG TITIDNQDIS KLNCKSLRRH IGIVQQEPVL MSGTIRDNIT YGLTYTPTKE 600
  601 EIRSVAKQCF CHNFITKFPN TYDTVIGPHG TLLSGGQKQR IAIARALIKK PTILILDEAT 660
  661 SALDVESEGA INYTFGQLMK SKSMTIVSIA HRLSTIRRSE NVIVLGHDGS VVEMGKFKEL 720
  721 YANPTSALSQ LLNEKAAPGP SDQQLQIEKV IEKEDLNESK EHDDQKKDDN DDNDNNHDND 780
  781 SNNQSPETKD NNSDDIEKSV EHLLKDAAKE ANPIKITPQP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] deduced N/A No confident structure predictions are available.
    2 View Details [135..257]
    [276..473]    		 PSI-BLAST 1660.0 MsbA
    3 View Details [258..275]
    [474..752]    		 PSI-BLAST 1660.0 MsbA
    4 View Details [753..820] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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