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Protein Overview: MDM38

General Information:
Name(s) found: MDM38 / YOL027C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 573 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: potassium ion transport [IMPLink to PubMed article]
    cellular potassium ion homeostasis [IMPLink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    protein insertion into mitochondrial membrane [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNFASRASC VTRRQASLYF VKNQGPRLIA STIPSCHWPL RAQGVQPNYP LSLRFYSTDK  60
   61 SKSVTKPVAP TSTDAPAKPK ETLMVKVKHA LKHYANGTKL LGYEIKVSTK LLIKFAQGYE 120
  121 LSRRERNQLR RTMGDVFRLI PFSAFLIIPF AELFLPFALK LFPNLLPSTY ESGKDKQAKR 180
  181 NKLIEIRKKT SEFLHETLEE SNLITYNTIE NAEKKQKFLN FFRKLYSAKE GKIMTFQHDE 240
  241 ISAIAQMFKN DSVLDNLSRP QLAAMSKFMS LRPFGNDNML RYQIRSKLKD IMNDDKTIDY 300
  301 EGVESLSQEE LYQACVSRGM KAYGVSKEDL VDNLKVWLEL RLRQKIPSVL MVLSSTFTFG 360
  361 GLPKENYSKA FSPLAEKKET KSKYDDLLDL YYDGILQVLS SIPDPVYNVA KLDVSESKSS 420
  421 AAETEAEKQV AEKKIKTEEK PEETAIPKEE ATAKESVIAT TASAVTPKLV VVNEKAETAK 480
  481 TEEISQEKEN AEPTDSAEAT EAEEKKTSDD NEFKLNVLKE QEELIKKEEE EAKQRASREH 540
  541 VPDDINLDEE EEAKSVPPIP ADQAAKTFVI KKD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MDM38 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] MSA 4.194995 View MSA. No confident structure predictions are available.
    2 View Details [230..386] PSI-BLAST 30.154902 Heavy meromyosin subfragment
    3 View Details [387..573] PSI-BLAST 30.154902 Heavy meromyosin subfragment


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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