Protein Overview: INN1

General Information:
Name(s) found:	INN1 / YNL152W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324177\|ref\|NP_014247.1\| Putative protein of unknown function; cytoplasmically localized protein proposed to function in phospholipid binding; YBL107C is an essential gene; Ynl152wp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S60975 hypothetical protein YNL152w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730789\|sp\|P53901.1\|YNP2_YEAST RecName: Full=Uncharacterized protein YNL152W [NCBI NR] gi\|1302110\|emb\|CAA96039.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1050800\|emb\|CAA63287.1\| N1765 [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YNL152W OS=Saccharomyces cerevisiae GN=YNL152W PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to cytoplasm [mips] Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function [SGD] YNL152W, Chr XIV from 346310-347539 [yeast_orfs2] Chr XIV from 346310-347539 [yeastorf3.fasta] (P53901) Hypothetical 46.2 kDa protein in YCK2-RPC8 intergenic region [4932.FASTACCERV.txt] YNL152W SGDID:S0005096, Chr XIV from 346313-347542, Uncharacterized ORF [yeastflysequest.fasta] Protein required for cell viability [Saccharomyces cerevisiae]gi\|1050800\|emb\|CAA63287.1\| N1765 [Saccharomyces cerevisiae]gi\|1302110\|emb\|CAA96039.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131898\|pir\|\|S60975 hypothetical protein YNL152w - [nrdb_11152004_Chlamydomonas] YNL152W SGDID:S000005096, Chr XIV from 346315-347544, Uncharacterized ORF, "Protein required for cell viability" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] INN1 SGDID:S000005096, Chr XIV from 346315-347544, Verified ORF, "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein required for cell viability; Ynl152wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] N1765 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized protein YNL152W [nr-271106-contam.fasta] INN1 SGDID:S000005096, Chr XIV from 346315-347544, Verified ORF, "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function" [yeast-bovrabprots.fasta] [chemostatdb.fasta] INN1 SGDID:S000005096, Chr XIV from 346313-347542, Genome Release 64-1-1, Verified ORF, "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function" [yeast-030211-contam.fasta] INN1 SGDID:S000005096, Chr XIV from 346313-347542, Genome Release 64-2-1, Verified ORF, "Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis" [20141208_orf_trans.fasta] YNL152W SGDID:S000005096, Chr XIV from 346313-347542, Genome Release 64-1-1, Verified ORF, "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	409 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ]
Biological Process:	biological_process [ND]
Molecular Function:	phospholipid binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEVWNGNQ GILSVYVSKA RDLPNLNKLD KQNVMLRLRI AHMTRASNTL HRAGQNPVFH  60
   61 YLEKFDITPE IKPLMYVEVY CDRRKKSPLP IGRCEIDLLN AIRADPKEGY CTWYELKRSG 120
  121 DEFAGTIFIE LTFTPKVPRL NRDDLNKEMD RLDSSMAMRP IPPLPTESEY DYVHGSTMRQ 180
  181 ITPQCVSTSH EDKDEGQPYR NGNVFSMSSK SDTAVLANSN DPIILPPTFS ASMGTTSTLE 240
  241 TNDTAISNTS NTKFHFANLR KLKEKINIFK NPDSSTNNCQ NESNKVDIEA LQKAIGVTSL 300
  301 SYDEDDDDDD ENDAFYSSSH RVSHNYNQPP LPPIPTRDDM SNYSSSRNTP LVRRDRPSRL 360
  361 DSSSPNSHPH PSGLNSPKLP PLPTTSNSNF NSRKNSMSPT RKRPPPRLS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RCY1	INN1	1	Unpublished Fields Lab Data
View Screen	NTA1	INN1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	INN1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..160]	PSI-BLAST	34.522879	Synaptogamin I
2	View Details	[161..284]	deduced	N/A	No confident structure predictions are available.
3	View Details	[285..353]	PSI-BLAST	5.522879	Ubiquitin ligase NEDD4 WWIII domain
4	View Details	[354..409]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2