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Protein Overview: DUS4

General Information:
Name(s) found: DUS4 / YLR405W [SGD]
Description(s) found:
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  • gi|6323437|ref|NP_013509.1| Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; Dus4p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|625099|gb|AAB82341.1| Ylr405wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|45271062|gb|AAS56912.1| YLR405W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2833204|sp|Q06063.1|DUS4_YEAST RecName: Full=tRNA-dihydrouridine synthase 4 [NCBI NR]
  • gi|1084647|pir||S55961 hypothetical protein YLR405w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • tRNA-dihydrouridine synthase 4 OS=Saccharomyces cerevisiae GN=DUS4 PE=1 SV=1 [Swiss-Prot]
  • DUS4 Member of dihydrouridine synthase family [mips]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p [SGD]
  • YLR405W, Chr XII from 929786-930889 [yeast_orfs2]
  • Chr XII from 929786-930889 [yeastorf3.fasta]
  • (Q06063) tRNA-dihydrouridine synthase 4 (EC 1.-.-.-) [4932.FASTACCERV.txt]
  • DUS4 SGDID:S0004397, Chr XII from 929787-930890, Uncharacterized ORF [yeastflysequest.fasta]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p [Saccharomyces cerevisiae]gi|1084647|pir||S55961 hypothetical protein YLR405w - yeast (Saccharomyces cerevisiae)gi|45271062|gb|AAS56912.1| YLR [nrdb_11152004_Chlamydomonas]
  • DUS4 SGDID:S000004397, Chr XII from 929787-930890, Uncharacterized ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • DUS4 SGDID:S000004397, Chr XII from 929788-930891, Uncharacterized ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [yeast-contam.fasta]
  • DUS4 SGDID:S000004397, Chr XII from 929788-930891, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • YLR405W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; Dus4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ylr405wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • tRNA-dihydrouridine synthase 4 [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUS4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DUS4 SGDID:S000004397, Chr XII from 929789-930892, Genome Release 64-1-1, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [yeast-030211-contam.fasta]
  • DUS4 SGDID:S000004397, Chr XII from 929789-930892, Genome Release 64-2-1, Verified ORF, "Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [20141208_orf_trans.fasta]
  • YLR405W SGDID:S000004397, Chr XII from 929789-930892, Genome Release 64-1-1, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 367 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: tRNA modification [ISSLink to PubMed article]
    Molecular Function: tRNA dihydrouridine synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHTMHIPSGD VLIPKPKLIT EETDPLHIIK TRQKTHGRPV TIAGPMVRYS KLPFRQLCRE  60
   61 YNVDIVYSPM ILAREYVRNE HARISDLSTN NEDTPLIVQV GVNNVADLLK FVEMVAPYCD 120
  121 GIGINCGCPI KEQIREGIGC ALIYNSDLLC SMVHAVKDKY GDKLRIETKI RIHEALDETV 180
  181 ELCRKLCDAG VDWITIHGRT RRTRSSQPAN LDAIKYIIEN ISDKNVPVIA NGDCFKLSDL 240
  241 ERITKYTGAH GVMAVRGLLS NPALFAGYTT CPWGCIEKFC YWALEFGGLP FQLAQHHLYC 300
  301 MLENMELKKS LLKKMMNLKN YISLIDWFNK TFEFKRYGED GFGMGVEIPY KANSCVQRSA 360
  361 SVVERQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DUS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] PSI-BLAST 29.39794 Dihydroorotate dehydrogenase
    2 View Details [280..367] PSI-BLAST 25.0 Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • tRNA dihydrouridine synthase activity
    		•  1.94490879164338 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.876786102965635 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.80115790656025 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.453918901387506 bayes_pls_golite062009
  • binding
    		•  0.256396206082349 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle