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Protein Overview: YLL016W

General Information:
Name(s) found: YLL016W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL017W [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1048 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: Ras protein signal transduction [TASLink to PubMed article]
    Molecular Function: Ras guanyl-nucleotide exchange factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPITSSPDLF YLNDCDVVYW YDLTRLVCHY VNLTERDLLA NEREKFLTSL DLLTAQITYV  60
   61 YMLFRNLRLV EDSFKKTLKK LIYTLSRFSI NANIWFHSTL FEEREAIASQ KDPERRSPLL 120
  121 QSILGTFQKF HFLLRLLHFL SNPNELTILP QLTPRFFKDS FNTISWNNPF LRKRLNQHMS 180
  181 HDLPRQMIKA VAGASGIVAE NIDEIPASKQ GTSCSSETSH HSPSAPFQRR RRGTIFSNVS 240
  241 GSSDESDTIW SKRKKPYPLN EETLSLVRAR KKQLDGKLKQ MIKSANEYLS NTANFSKMLN 300
  301 FEMNFKTYEE VSGTIPIIDI LENLDLTIFL NLRELGDENR VFDEDVAIDD EDEEFLKHSL 360
  361 SSLSYILSDY FNMKQYFHDV VVKFIIVAQH LTLEDPFVFS PMQNDLPTGY YEPMKPSSLN 420
  421 LDNAKDKKNG SQNTDIQEEE DEYEPDPDSL ILFHNLINQD SDFNDLKFFN LAHVFKKSCD 480
  481 DYFDVLKLAI EFVNQLILER ENLLNYAARM MKNNITELLL RGEEGYGSYD GGETAEKSDT 540
  541 NAVYADSDTK DNDEWRDSQV KLPRYLQREY DSELIWGSNN RIKGGSKHAL ISYLTDNEKK 600
  601 DLFFDITFLI TFRSIFTTTE FLSYLISQYN LDPPEDLCFE EYNEWVTKKL IPVKCRVVEI 660
  661 MTTFFKQYWF LGYDEPDLAT LNLDYFAQVA IKENITGSVE LLKEVNQKFK HGNIQEATAP 720
  721 MKTLDQQICQ DHYSGTLYST TESILAVDPV LFATQLTILE HEIYCEITIF DCLQKIWKNK 780
  781 YTKSYGASPG LNEFISFANK LTNFISYSVV KEADKSKRAK LLSHFIFIAE YCRKFNNFSS 840
  841 MTAIISALYS SPIYRLEKTW QAVIPQTRDL LQSLNKLMDP KKNFINYRNE LKSLHSAPCV 900
  901 PFFGVYLSDL TFTDSGNPDY LVLEHGLKGV HDEKKYINFN KRSRLVDILQ EIIYFKKTHY 960
  961 DFTKDRTVIE CISNSLENIP HIEKQYQLSL IIEPKPRKKV VPNSNSNNKS QEKSRDDQTD1020
 1021 EGKTSTKKDR FPKFQLHKTK KKAPKVSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] MSA 1.004956 View MSA. No confident structure predictions are available.
    2 View Details [159..526] deduced N/A No confident structure predictions are available.
    3 View Details [527..709]
    [911..947]    		 PSI-BLAST 382.9794 Son of sevenless protein homolog 1 (sos-1)
    4 View Details [710..910]
    [948..1048]    		 PSI-BLAST 382.9794 Son of sevenless protein homolog 1 (sos-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  0.597587183571285 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.32323692785606 bayes_pls_golite062009
  • protein binding
    		•  0.29116370406325 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle