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View Structure Prediction Details

Protein: YLL016W
Organism: Saccharomyces cerevisiae
Length: 1048 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLL016W.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..1048] [206..1250]
gi|31077168 - gi|31077168|sp|P14771.4|SDC25_YEAST RecName: Full=Guanine nucleotide exchange factor SDC25
0.0 [1..1048] [206..1253]
CDC25_LACKL - Cell division control protein 25 (Fragment) OS=Lachancea kluyveri GN=CDC25 PE=3 SV=1
0.0 [117..1043] [200..1089]
gi|6678063, gi|5... - gi|6678063|ref|NP_033257.1| Son of sevenless homolog 1 [Mus musculus], gi|54135|emb|CAA77662.1| mous...
0.0 [495..1033] [532..1078]
gi|147897729, gi... - gi|208965546|dbj|BAG72787.1| son of sevenless homolog 1 [synthetic construct], gi|147897729|gb|AAI40...
SOS1 - son of sevenless homolog 1 (Drosophila)
HGNC:11187|MIM:1... - of sevenless homolog 1 (Drosophila)
0.0 [495..1033] [515..1061]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPITSSPDLF YLNDCDVVYW YDLTRLVCHY VNLTERDLLA NEREKFLTSL DLLTAQITYV  60
   61 YMLFRNLRLV EDSFKKTLKK LIYTLSRFSI NANIWFHSTL FEEREAIASQ KDPERRSPLL 120
  121 QSILGTFQKF HFLLRLLHFL SNPNELTILP QLTPRFFK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSFNTISWNN PFLRKRLNQH MSHDLPRQMI KAVAGASGIV AENIDEIPAS KQGTSCSSET  60
   61 SHHSPSAPFQ RRRRGTIFSN VSGSSDESDT IWSKRKKPYP LNEETLSLVR ARKKQLDGKL 120
  121 KQMIKSANEY LSNTANFSKM LNFEMNFKTY EEVSGTIPII DILENLDLTI FLNLRELGDE 180
  181 NRVFDEDVAI DDEDEEFLKH SLSSLSYILS DYFNMKQYFH DVVVKFIIVA QHLTLEDPFV 240
  241 FSPMQNDLPT GYYEPMKPSS LNLDNAKDKK NGSQNTDIQE EEDEYEPDPD SLILFHNLIN 300
  301 QDSDFNDLKF FNLAHVFKKS CDDYFDVLKL AIEFVNQLIL ERENLLNYAA RMMKNNITEL 360
  361 LLRGEEGY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [527-709]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSYDGGETAE KSDTNAVYAD SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS  60
   61 KHALISYLTD NEKKDLFFDI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV 120
  121 TKKLIPVKCR VVEIMTTFFK QYWFLGYDEP DLATLNLDYF AQVAIKENIT GSVELLKEVN 180
  181 QKF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [911-947]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFTDSGNPDY LVLEHGLKGV HDEKKYINFN KRSRLVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 382.9794
Match: 1bkdS_
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [710-910]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHGNIQEATA PMKTLDQQIC QDHYSGTLYS TTESILAVDP VLFATQLTIL EHEIYCEITI  60
   61 FDCLQKIWKN KYTKSYGASP GLNEFISFAN KLTNFISYSV VKEADKSKRA KLLSHFIFIA 120
  121 EYCRKFNNFS SMTAIISALY SSPIYRLEKT WQAVIPQTRD LLQSLNKLMD PKKNFINYRN 180
  181 ELKSLHSAPC VPFFGVYLSD L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [948-1048]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILQEIIYFKK THYDFTKDRT VIECISNSLE NIPHIEKQYQ LSLIIEPKPR KKVVPNSNSN  60
   61 NKSQEKSRDD QTDEGKTSTK KDRFPKFQLH KTKKKAPKVS K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 382.9794
Match: 1bkdS_
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.597587183571285 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.32323692785606 bayes_pls_golite062009
protein binding 0.29116370406325 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle