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Protein Overview: STE24

General Information:
Name(s) found: STE24 / YJR117W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: peptide pheromone maturation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: prenyl-dependent CAAX protease activity [IDALink to PubMed articleLink to PubMed article]
    metalloendopeptidase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDLKTILDH PNIPWKLIIS GFSIAQFSFE SYLTYRQYQK LSETKLPPVL EDEIDDETFH  60
   61 KSRNYSRAKA KFSIFGDVYN LAQKLVFIKY DLFPKIWHMA VSLLNAVLPV RFHMVSTVAQ 120
  121 SLCFLGLLSS LSTLVDLPLS YYSHFVLEEK FGFNKLTVQL WITDMIKSLT LAYAIGGPIL 180
  181 YLFLKIFDKF PTDFLWYIMV FLFVVQILAM TIIPVFIMPM FNKFTPLEDG ELKKSIESLA 240
  241 DRVGFPLDKI FVIDGSKRSS HSNAYFTGLP FTSKRIVLFD TLVNSNSTDE ITAVLAHEIG 300
  301 HWQKNHIVNM VIFSQLHTFL IFSLFTSIYR NTSFYNTFGF FLEKSTGSFV DPVITKEFPI 360
  361 IIGFMLFNDL LTPLECAMQF VMSLISRTHE YQADAYAKKL GYKQNLCRAL IDLQIKNLST 420
  421 MNVDPLYSSY HYSHPTLAER LTALDYVSEK KKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) RCE1 STE24

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data STE24 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] deduced N/A No confident structure predictions are available.
    2 View Details [227..453] Pfam 67.200659 Peptidase family M48 No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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