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Protein Overview: YHC3

General Information:
Name(s) found: YHC3 / YJL059W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 408 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of intracellular pH [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    arginine transport [IGILink to PubMed article][IMPLink to PubMed article]
    basic amino acid transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKSHQIYC YFWLFGLINN VLYVVILSAA VDIVGPTLPK SLVLLADIFP SLAIKLCSPF  60
   61 FIDRIKYSYR IWSLITMSCL GMFLVSFKNL FVCLLGISFA SISSGFGEVT FLQLTHYYKQ 120
  121 ISLNGWSSGT GGAGIIGGAS YMFLTSIFKV PVKLTLLVFS LLPFAFLFYF KLESNDTNLT 180
  181 YQSLQQIDEA EDDQLVPFPV AFTHTNASQS LYSTRQHILQ TVKRLRRLVF PYMVPLTTVY 240
  241 LFEYLINQAV APTLLFPING DERSKSMPFF FHKYRDIYVT YGTLYQLGVF ISRSFGHLMR 300
  301 MRSLYILAFL QGVNLCITVL QSWFYVTHSP WAVMILIFYE GFLGGASYVN TFLNILEQED 360
  361 PDETEFAMGA VSIADSFGVF LAALLGLGLE PKLCRHQIAD DRPWCRME

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..408] Pfam 269.721246 CLN3 protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.82096685159505 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.34396155292818 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.32643461660963 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.2506965512085 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.05049771748124 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.02370427376594 bayes_pls_golite062009
  • binding
    		•  1.9065830290222 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.62538016506437 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.46819549608723 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  0.869150152038001 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.339747214378126 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.339747214378126 bayes_pls_golite062009
  • symporter activity
    		•  0.327558013224678 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.327558013224678 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  0.273403673499648 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  0.273403673499648 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.222664452597504 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle