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Protein Overview: DOT5

General Information:
Name(s) found: DOT5 / YIL010W [SGD]
Description(s) found:
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  • gi|731778|sp|P40553.1|DOT5_YEAST RecName: Full=Peroxiredoxin DOT5; AltName: Full=Thioredoxin reductase; AltName: Full=Nuclear thiol peroxidase; Short=nTPx; AltName: Full=Disrupter of telomere silencing protein 5 [NCBI NR]
  • gi|6322180|ref|NP_012255.1| Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth; Dot5p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48445 hypothetical protein YIL010w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|558392|emb|CAA86239.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|45270486|gb|AAS56624.1| YIL010W [Saccharomyces cerevisiae] [NCBI NR]
  • Peroxiredoxin DOT5 OS=Saccharomyces cerevisiae GN=DOT5 PE=1 SV=1 [Swiss-Prot]
  • DOT5 Protein involved in derepression of telomeric silencing [mips]
  • Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth [SGD]
  • DOT5, Chr IX from 334879-335526 [yeast_orfs2]
  • Chr IX from 334879-335526 [yeastorf3.fasta]
  • (P40553) Disrupter of telomere silencing protein 5 [4932.FASTACCERV.txt]
  • DOT5 SGDID:S0001272, Chr IX from 334879-335526, Verified ORF [yeastflysequest.fasta]
  • Dot5p [Saccharomyces cerevisiae]gi|558392|emb|CAA86239.1| unnamed protein product [Saccharomyces cerevisiae]gi|45270486|gb|AAS56624.1| YIL010W [Saccharomyces cerevisiae]gi|626354|pir||S48445 hypothetical protein YIL010w - yeast (Saccharomyces cerevisia [nrdb_11152004_Chlamydomonas]
  • DOT5 SGDID:S000001272, Chr IX from 334879-335526, Verified ORF, "Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth; Dot5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YIL010W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Peroxiredoxin DOT5 (Thioredoxin reductase) (Nuclear thiol peroxidase) (nTPx) (Disrupter of telomere silencing protein 5) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Peroxiredoxin DOT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DOT5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DOT5 SGDID:S000001272, Chr IX from 334882-335529, Genome Release 64-1-1, Verified ORF, "Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth" [yeast-030211-contam.fasta]
  • DOT5 SGDID:S000001272, Chr IX from 334882-335529, Genome Release 64-2-1, Verified ORF, "Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth" [20141208_orf_trans.fasta]
  • YIL010W SGDID:S000001272, Chr IX from 334882-335529, Genome Release 64-1-1, Verified ORF, "Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEALRRSTR IAISKRMLEE EESKLAPIST PEVPKKKIKT GPKHNANQAV VQEANRSSDV  60
   61 NELEIGDPIP DLSLLNEDND SISLKKITEN NRVVVFFVYP RASTPGCTRQ ACGFRDNYQE 120
  121 LKKYAAVFGL SADSVTSQKK FQSKQNLPYH LLSDPKREFI GLLGAKKTPL SGSIRSHFIF 180
  181 VDGKLKFKRV KISPEVSVND AKKEVLEVAE KFKEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DOT5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 96.28043 Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.66884588063322 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.8187537496904 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • selenium binding
    		•  1.1082524159827 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle