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Protein Overview: NSG1

General Information:
Name(s) found: NSG1 / YHR133C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 291 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: sterol biosynthetic process [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKKSKNQL NTGGVPNGVH NTKKEAALPP LGNKLGSASF TAINTLTKPA LFSFYDDDIT  60
   61 KNEGNVYDKA LLSNASQLEM VPPSATARHE RSLYAKIINT IAAFFILFIA GILFPMISEC 120
  121 LFDNDQLAKG DIVSFLKHGI EIKNKIVAEP DMVPDWAVFG TEGVIFGSIV PFIDSFVRYQ 180
  181 HQPKTRSSVY KNTLGSFIRC ANTLLGLIFG IRKLEWSSSL QAAGAWSLLN IVLWLFFDGT 240
  241 LTVFFPGLVI GALSAFTCSQ CFSQLSLALY FIDFYFFGFL MFSKLGRYLF N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LAS17 NSG1 2 Drees BL, et al. (2001)
    View Screen RPN11 NSG1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NSG1 Huh WK, et al. (2003)
    View Data NSG1 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle