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Protein Overview: BIO2

General Information:
Name(s) found: BIO2 / YGR286C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 375 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: biotin biosynthetic process [TASLink to PubMed article]
    Molecular Function: biotin synthase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSTIYRHLS TARPALTKYA TNAAVKSTTA SSEASTLGAL QYALSLDEPS HSWTKSQLKE  60
   61 IYHTPLLELT HAAQLQHRKW HDPTKVQLCT LMNIKSGGCS EDCKYCAQSS RNDTGLKAEK 120
  121 MVKVDEVIKE AEEAKRNGST RFCLGAAWRD MKGRKSAMKR IQEMVTKVND MGLETCVTLG 180
  181 MVDQDQAKQL KDAGLTAYNH NIDTSREHYS KVITTRTYDD RLQTIKNVQE SGIKACTGGI 240
  241 LGLGESEDDH IGFIYTLSNM SPHPESLPIN RLVAIKGTPM AEELADPKSK KLQFDEILRT 300
  301 IATARIVMPK AIIRLAAGRY TMKETEQFVC FMAGCNSIFT GKKMLTTMCN GWDEDKAMLA 360
  361 KWGLQPMEAF KYDRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BIO2 OAF3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BIO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] deduced N/A No confident structure predictions are available.
    2 View Details [117..262] PSI-BLAST 2.522879 Methylenetetrahydrofolate reductase
    3 View Details [263..375] MSA 6.846996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • biotin synthase activity
    		•  4.96431653338581 bayes_pls_golite062009
  • radical SAM enzyme activity
    		•  4.81217611621334 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  3.43375708969779 bayes_pls_golite062009
  • transferase activity, transferring sulfur-containing groups
    		•  2.79703059227143 bayes_pls_golite062009
  • coproporphyrinogen oxidase activity
    		•  1.98937742831419 bayes_pls_golite062009
  • catalytic activity
    		•  1.48331922124015 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  1.37188743230327 bayes_pls_golite062009
  • binding
    		•  1.19681284943457 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.18901545014659 bayes_pls_golite062009
  • transferase activity
    		•  0.685192555939835 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.593156857804038 bayes_pls_golite062009
  • protein binding
    		•  0.374124957429525 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle