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Protein Overview: TMT1

General Information:
Name(s) found: TMT1 / YER175C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 299 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: trans-aconitate 3-methyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTFSASDFN SERYSSSRPS YPSDFYKMID EYHDGERKLL VDVGCGPGTA TLQMAQELKP  60
   61 FEQIIGSDLS ATMIKTAEVI KEGSPDTYKN VSFKISSSDD FKFLGADSVD KQKIDMITAV 120
  121 ECAHWFDFEK FQRSAYANLR KDGTIAIWGY ADPIFPDYPE FDDLMIEVPY GKQGLGPYWE 180
  181 QPGRSRLRNM LKDSHLDPEL FHDIQVSYFC AEDVRDKVKL HQHTKKPLLI RKQVTLVEFA 240
  241 DYVRTWSAYH QWKQDPKNKD KEDVADWFIK ESLRRRPELS TNTKIEVVWN TFYKLGKRV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TMT1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151]
    [179..222]    		 PSI-BLAST 21.0 CmaA1
    2 View Details [152..178]
    [223..299]    		 PSI-BLAST 21.0 CmaA1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle