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Protein Overview: MTH1

General Information:
Name(s) found: MTH1 / YDR277C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 433 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: signal transduction [IGILink to PubMed article][IMPLink to PubMed article]
    glucose transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFVSPPPATS KNQVLQRRPL ESTNSNHGFA SSLQAIPENT MSGSDNASFQ SLPLSMSSSQ  60
   61 STTSSRRENF VNAPPEYTDR ARDEIKKRLL ASSPSRRSHH SSSMHSASRR SSVAESGSLL 120
  121 SDNASSYQSS IFSAPSTVHT QLTNDSSFSE FPNHKLITRV SLDEALPKTF YDMYSPDILL 180
  181 ADPSNILCNG RPKFTKRELL DWDLNDIRSL LIVEKLRPEW GNQLPEVITV GDNMPQFRLQ 240
  241 LLPLYSSDET IIATLVHSDL YMEANLDYEF KLTSAKYTVA TARKRHEHIT GRNEAVMNLS 300
  301 KPEWRNIIEN YLLNIAVEAQ CRFDFKQRCS EYKKWKLQQS NLKRPDMPPP SIIPRKNSTE 360
  361 TKSLLKKALL KNIQLKNPNN NLDELMMRSS AATNQQGKNK VSLSKEEKAT IWSQCQAQVY 420
  421 QRLGLDWQPD SVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

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    View Screen SAS3 MTH1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..433] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle