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Protein Overview: CRF1

General Information:
Name(s) found: CRF1 / YDR223W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of transcription [IDALink to PubMed article]
    Molecular Function: transcription repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLSAPVNST VRRKPHSPNK KKPKETGTAA SFSSSSSTVV LSSNNDGSFD ALWDPSISKA  60
   61 SDFESSYISA KRLKPESSNR QKKKNSYKYS REENTNEVEE KTSLGSSSKT EADNIFNDQL 120
  121 TSAGNTTYVS NKRDVNFGAN SAVVLLGLPT SKSESHRQYH SPSASTTNED EEDIGVDILV 180
  181 DNHIDSCETV SINNNRGITH QYPETESDVD FDEAVILTPM DGTDKGVKNP RPLEKKYSSS 240
  241 CFEDRTPLNL DDGHFSECNH FSTLDVSSFF HLNEHVHKID EVELDGPDRT FSLDNVAINT 300
  301 RKKDIDCLYN SSREDLSNLT CSSEGPRNDS YDSDYNIDEV TYRDDESTDE DESLPTPDRK 360
  361 RKKIGHKACE ILDSKRIGIK VPKLYVWSLS DKPFSVIDGL CTKSLYPLSD DINTPESLSS 420
  421 CSSSVSSREN QKGDATFDND AMIADLLNIG GLEVEKASNG HIELIGE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202] deduced N/A No confident structure predictions are available.
    2 View Details [203..467] MSA 1.002921 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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