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Protein Overview: NHP2

General Information:
Name(s) found: NHP2 / YDL208W [SGD]
Description(s) found:
Found 16 descriptions.
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  • Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 173 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [TASLink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: rRNA modification [TASLink to PubMed article]
    rRNA pseudouridine synthesis [IMPLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNGSLGSRE TETSAVKMGK DNKEHKESKE SKTVDNYEAR MPAVLPFAKP LASKKLNKKV  60
   61 LKTVKKASKA KNVKRGVKEV VKALRKGEKG LVVIAGDISP ADVISHIPVL CEDHSVPYIF 120
  121 IPSKQDLGAA GATKRPTSVV FIVPGSNKKK DGKNKEEEYK ESFNEVVKEV QAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NSL1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 191.9897 Spliceosomal 15.5kd protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • snoRNA binding
    		•  4.95788328272916 bayes_pls_golite062009
  • RNA binding
    		•  4.7078532107994 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.68798692352408 bayes_pls_golite062009
  • structural molecule activity
    		•  3.12718364266877 bayes_pls_golite062009
    		• 2.493460131667 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39301463005357 bayes_pls_golite062009
  • binding
    		•  1.74903521776827 bayes_pls_golite062009
  • mRNA binding
    		•  1.63088955572344 bayes_pls_golite062009
  • catalytic activity
    		•  0.264002643439785 bayes_pls_golite062009
  • protein binding
    		•  0.131685221037103 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle