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Protein Overview: SHM1

General Information:
Name(s) found: SHM1 / YBR263W [SGD]
Description(s) found:
Found 11 descriptions.
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  • Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: one-carbon metabolic process [TASLink to PubMed article]
    Molecular Function: glycine hydroxymethyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILSVICWFL VHCLFCPPSV QEIEYKKDSL FFFRYFAYWW SMRKKILKAI ASWRRANYQK  60
   61 SSSRHFHIES HSLSIMFPRA SALAKCMATV HRRGLLTSGA QSLVSKPVSE GDPEMFDILQ 120
  121 QERHRQKHSI TLIPSENFTS KAVMDLLGSE LQNKYSEGYP GERYYGGNEI IDKSESLCQA 180
  181 RALELYGLDP AKWGVNVQPL SGAPANLYVY SAIMNVGERL MGLDLPDGGH LSHGYQLKSG 240
  241 TPISFISKYF QSMPYHVDHT TGLIDYDNLQ VLAKAFRPKV IVAGTSAYSR LIDYARFKEI 300
  301 SQGCGAYLMS DMAHISGLVA ANVVPSPFEH SDIVTTTTHK SLRGPRGAMI FFRKGIKSVT 360
  361 KKGKEIPYEL EKKINFSVFP GHQGGPHNHT IGAMAVALKQ AMSPEFKEYQ QKIVDNSKWF 420
  421 AQELTKMGYK LVSGGTDNHL IVIDLSGTQV DGARVETILS ALNIAANKNT IPGDKSALFP 480
  481 SGLRIGTPAM TTRGFGREEF SQVAKYIDSA VKLAENLKTL EPTTKLDARS RLNEFKKLCN 540
  541 ESSEVAALSG EISKWVGQYP VPGDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [93..137]
    [411..565]    		 PSI-BLAST 1562.0 Serine hydroxymethyltransferase
    3 View Details [138..410] PSI-BLAST 1562.0 Serine hydroxymethyltransferase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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