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Protein Overview: CYC3

General Information:
Name(s) found: CYC3 / YAL039C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: cytochrome c-heme linkage [IDALink to PubMed article]
    Molecular Function: holocytochrome-c synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND RINPLNNMPE  60
   61 LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM YNAMVRKGKI GGSGEVAEDA 120
  121 VESMVQVHNF LNEGCWQEVL EWEKPHTDES HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF 180
  181 PSHFSQELPF DRHDWIVLRG ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA 240
  241 LDSLDNAKDR MTRFLDRMIS GPSSSSSAP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CYC3 CYT2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CYC3 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..269] Pfam 171.522879 Cytochrome c/c1 heme lyase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle