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Protein Overview: Adar-PC

General Information:
Name(s) found: Adar-PC / FBpp0100009 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Adenosine deaminase acting on RNA is referred to in FlyBase by the symbol Dmel\Adar (CG12598, FBgn0026086). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1667783..1678034. It has the cytological map location 2B9. There is experimental evidence that it has the molecular function</span>: double-stranded RNA adenosine deaminase activity. There is experimental evidence that it is involved in the biological process</span>: response to hypoxia; adult behavior; locomotory behavior; adenosine to inosine editing; adult locomotory behavior; response to heat; mRNA modification; regulation of membrane potential. 29 alleles are reported. The phenotypes of these alleles are annotated with: retina; medulla; optic lobe; lobula; adult central nervous system; photoreceptor cell; wing; lamina; adult brain. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 186 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: response to heat [IMP]
    regulation of membrane potential [IMP]
    response to hypoxia [IMP][TAS]
    locomotory behavior [IMP]
    adenosine to inosine editing [IMP]
    adult locomotory behavior [IMP]
    RNA processing [IEA]
    adult behavior [IMP]
    mRNA modification [IDA][IMP][TAS]
    Molecular Function: double-stranded RNA binding [IEA][ISS]
    double-stranded RNA adenosine deaminase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNSANNNSP QHPVSAPSDI NMNGYNRKLP QKRGYEMPKY SDPKKKMCKE RIPQPKNTVA  60
   61 MLNELRHGLI YKLESQTGPV HAPLFTISVE VDGQKYLGQG RSKKVARIEA AATALRSFIQ 120
  121 FKDGAVLSPL KPAGNLDFTS DEHLENGIEN LSSSKMFEII QTMLTEKLSN PTSLEQPTFC 180
  181 MSQSKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 27.69897 RNase III endonuclease catalytic domain; RNase III, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.602312874472495 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle