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Protein Overview: NOS3_RAT

General Information:
Name(s) found: NOS3_RAT [Swiss-Prot]
Description(s) found:
Found 7 descriptions.
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  • Nitric oxide synthase, endothelial OS=Rattus norvegicus GN=Nos3 PE=1 SV=4 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1202 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    caveola [UNKNOWN][IEA]
    soluble fraction [IDA]
    cytoskeleton [IEA]
    apical part of cell [IDA]
    cytoplasm [UNKNOWN][IDA]
    cytosol [UNKNOWN]
    Golgi membrane [UNKNOWN]
    Golgi apparatus [IDA]
    nucleolus [IDA]
    plasma membrane [IEA]
    Biological Process: response to cytokine stimulus [IEP]
    response to hyperoxia [IEP]
    negative regulation of muscle hyperplasia [IEA]
    response to lipoprotein stimulus [IEP]
    positive regulation of guanylate cyclase activity [UNKNOWN]
    response to amino acid stimulus [IEP]
    negative regulation of potassium ion transport [UNKNOWN][IEA]
    endothelial cell migration [UNKNOWN][IEA]
    positive regulation of angiogenesis [IEA]
    ovulation from ovarian follicle [UNKNOWN][IEA]
    response to ethanol [IEP]
    negative regulation of hydrolase activity [UNKNOWN][IEA]
    response to hypoxia [IEP]
    angiogenesis [UNKNOWN]
    negative regulation of smooth muscle cell proliferation [IMP]
    negative regulation of calcium ion transport [UNKNOWN][IEA]
    response to fluid shear stress [UNKNOWN][IEA]
    lung development [UNKNOWN][IEA]
    signal transduction [IMP]
    response to organic cyclic substance [IEP]
    regulation of systemic arterial blood pressure by endothelin [UNKNOWN][IEA]
    aging [IEP]
    response to peptide hormone stimulus [IEP]
    arginine catabolic process [UNKNOWN][IEA]
    regulation of sodium ion transport [UNKNOWN][IEA]
    blood vessel remodeling [IEA]
    regulation of blood vessel size [IEA]
    smooth muscle hyperplasia [IEA]
    response to drug [IEP]
    response to estradiol stimulus [IEP]
    lipopolysaccharide-mediated signaling pathway [UNKNOWN][IEA]
    response to lipopolysaccharide [IEP]
    oxidation reduction [IEA]
    nitric oxide biosynthetic process [UNKNOWN][IMP]
    response to lead ion [IEP]
    Molecular Function: arginine binding [UNKNOWN][IEA]
    calmodulin binding [IEA]
    tetrahydrobiopterin binding [UNKNOWN][IEA]
    NADP or NADPH binding [IEA]
    protein binding [UNKNOWN][IDA][IPI]
    nitric-oxide synthase activity [UNKNOWN][IDA][IMP]
    FMN binding [IEA]
    oxidoreductase activity [IEA]
    metal ion binding [IEA]
    FAD binding [IEA]
    actin monomer binding [UNKNOWN][IEA]
    heme binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APVPPSPTRP APDHSPPLTR  60
   61 PPDGPKFPRV KNWEVGSITY DTLSAQAQQD GPCTPRRCLG SLVFPRKLQS RPTQGPSPTE 120
  121 QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ EVEAEVVATG TYQLRESELV FGAKQAWRNA 180
  181 PRCVGRIQWG KLQVFDARDC RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRYAGRGDF 240
  241 RIWNSQLVRY AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE 300
  301 LFTLPPELVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA PFSGWYMSSE 360
  361 IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE INVAVLYSYQ LAKVTIVDHH 420
  421 AATASFMKHL ENEQKARGGC PADWAWIVPP ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK 480
  481 GSAAKGTGIT RKKTFKEVAN AVKISASLMG TVMAKRVKAT ILYGSETGRA QSYAQQLGRL 540
  541 FRKAFDPRVL CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP 600
  601 RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG LGSRAYPHFC 660
  661 AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA AFQAACETFC VGEDAKAAAR 720
  721 DIFSPKRSWK RQRYRLSTQA ESLQLLPRLT HVHRRKMFQA TILSVENLQS SKSTRATILV 780
  781 RLDTGSQEGL QYQPGDHIGV CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP 840
  841 PGWVRDPRLP PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE 900
  901 EWKWFRCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG EIHLTVAVLA 960
  961 YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL PPDPNLPCIL VGPGTGIAPF1020
 1021 RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP1080
 1081 GSPKTYVQDL LRTELAAEVH RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGSMELDE1140
 1141 AGDVIGVLRD QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPTQETP1200
 1201 GS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle