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Protein Overview: Alr-PA

General Information:
Name(s) found: Alr-PA / FBpp0074563 [FlyBase]
Description(s) found:
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  • gi|221499725|ref|NP_608353.2| CG12534 [Drosophila melanogaster] [NCBI NR]
  • gi|220901831|gb|AAF49017.3| CG12534 [Drosophila melanogaster] [NCBI NR]
  • The gene Augmenter of liver regeneration is referred to in FlyBase by the symbol Dmel\Alr (CG12534, FBgn0031068). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19642952..19644204. It has the cytological map location 18F1. Based on sequence similarity, it is predicted to have molecular function</span>: flavin-linked sulfhydryl oxidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 5 alleles are reported. The phenotype of these alleles is annotated with: imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • (AE003513) CG12534 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • type=protein; loc=X:join(19642961..19643341,19643421..19643662,19643722..19643884); ID=FBpp0074563; name=CG12534-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_pro [fly-100309-contam.fasta]
  • type=protein; loc=X:join(19642961..19643341,19643421..19643662,19643722..19643884); ID=FBpp0074563; name=CG12534-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(19642961..19643341,19643421..19643662,19643722..19643884); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Augmenter of liver regeneration OS=Drosophila melanogaster GN=Alr PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(19642961..19643341,19643421..19643662,19643722..19643884); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017,FlyMine:FBpp0074563,modMine:FBpp0074563; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(19748928..19749308,19749388..19749629,19749689..19749851); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017,FlyMine:FBpp0074563,modMine:FBpp0074563; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(19748928..19749308,19749388..19749629,19749689..19749851); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017,FlyMine:FBpp0074563,modMine:FBpp0074563; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of C0PVB3, Sulfhydryl oxidase OS=Drosophila melanogaster GN=Alr PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0074563 type=protein; loc=X:join(19748928..19749308,19749388..19749629,19749689..19749851); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017,FlyMine:FBpp0074563,modMine:FBpp0074563; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(19748928..19749308,19749388..19749629,19749689..19749851); ID=FBpp0074563; name=Alr-PA; parent=FBgn0031068,FBtr0074794; dbxref=FlyBase:FBpp0074563,FlyBase_Annotation_IDs:CG12534-PA,GB_protein:AAF49017.2,REFSEQ:NP_608353,GB_protein:AAF49017,REFSEQ:NP_608353,GB_protein:AAF49017,UniProt/TrEMBL:Q7KUU5,FlyMine:FBpp0074563,modMine:FBpp0074563; MD5=0b87b405cd2cb2c3fecc7fb8474d6e3a; length=261; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 261 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: flavin-linked sulfhydryl oxidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIFTIAERSF KILELPTTPT LLLRRQSHNY GYDYISPTHI ELSREATRLV IRRLQRTVLR  60
   61 LIRDPDFIMS AEANPEMDKE HHESPFAANR KAGASGAGKQ DSNCRTCNDF KSWSKQQRLI 120
  121 SNVQSAKVKH MAAAEKLTVN AAEDPLPRDD CPLDKVRLGI STWGLLHTMA AFYSDNPTDT 180
  181 EKRDMKTFFE VLSRLYPCEF CAKDFRTDLD VNPINVNSQK ELALWLCKFH NRVNDKLGKP 240
  241 LFDCTKVNER WRDGWLDGSC D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..139] MSA 1.062994 View MSA. No confident structure predictions are available.
    3 View Details [140..261] PSI-BLAST 46.39794 Augmenter of liver regeneration

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor
    		•  8.87150227689427 bayes_pls_golite062009
  • thiol oxidase activity
    		•  8.35075284009652 bayes_pls_golite062009
  • flavin-linked sulfhydryl oxidase activity
    		•  3.45360739809667 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.80346464149611 bayes_pls_golite062009
  • binding
    		•  1.31466847278576 bayes_pls_golite062009
  • protein binding
    		•  0.425029114798138 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle