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Protein Overview: dab-1

General Information:
Name(s) found: dab-1 / CE37844 [WormBase]
Description(s) found:
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  • WBGene00000894 locus:dab-1 status:Confirmed UniProt:Q9U3A6 protein_id:CAB54271.3 [WormBase]
  • gi|71992767|ref|NP_495730.2| DAB (Drosophila disabled) homolog family member (dab-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|58081965|emb|CAB54271.3| C. elegans protein M110.5b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • CE37844 WBGene00000894 locus:dab-1 status:Confirmed TR:Q9U3A6 protein_id:CAB54271.3 [wormpep150.fasta]
  • 37844 WBGene00000894 locus:dab-1 status:Confirmed TR:Q9U3A6 protein_id:CAB54271.3 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37844 WBGene00000894 locus:dab-1 status:Confirmed TR:Q9U3A6 protein_id:CAB54271.2 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • CE37844 WBGene00000894 locus:dab-1 status:Confirmed UniProt:Q9U3A6_CAEEL protein_id:CAB54271.3 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37844 WBGene00000894 locus:dab-1 status:Confirmed UniProt:Q9U3A6_CAEEL protein_id:CAB54271.3| [wormORF-contam.fasta]
  • DAB (Drosophila disabled) homolog family member (dab-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein M110.5b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE37844 WBGene00000894 locus:dab-1 status:Confirmed UniProt:Q9U3A6 protein_id:CAB54271.3 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
    • Organism: Caenorhabditis elegans
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: AP-1 adaptor complex [IDALink to PubMed article]
    vesicle [IDALink to PubMed article]
    AP-2 adaptor complex [IDALink to PubMed article]
    Golgi-associated vesicle [IDALink to PubMed article]
    Biological Process: molting cycle, protein-based cuticle [IMPLink to PubMed article]
    vesicle-mediated transport [IEPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    oviposition [IMPLink to PubMed articleLink to PubMed article]
    protein secretion [IMPLink to PubMed article]
    cell migration [IMPLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: clathrin heavy chain binding [IDALink to PubMed article]
    protein domain specific binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQKSDISVE TANATSGKPN PPSPKSRLAM LKRTKKASNA SSDPFRFQNN GISYKGKLIG  60
   61 EQDVDKARGD AMCAEAMRTA KSIIKAAGAH KTRITLQINI DGIKVLDEKS GAVLHNFPVS 120
  121 RISFIARDSS DARAFGLVYG EPGGKYKFYG IKTAQAADQA VLAIRDMFQV VFEMKKKQIE 180
  181 QVKQQQIQDG GAEISSKKEG GVAVADLLDL ESELQQIERG VQQLSTVPTN CDAFGASPFG 240
  241 DPFVDSFNST ATSNGTANMS GTQVPFGGLQ LPQVQQMQMP MVQIPQQSHQ NWPTSGAGSF 300
  301 DAWGQQQQQQ QMHHAHSTPA FGTNGFSDTN PFASAFNTQA RPPPLPTVAP TQYRDPFSVH 360
  361 SSAIPNSNID WTGTGTTKEN MAPSTNIQQQ QSSLHHASTF ANFGDNKFRA ETWSEKKVTS 420
  421 LEEAFTKLVD MDALVGGQGI KETKKNPFEH ILNPPKASLN SMSTTCSAAQ MAATQQHTTS 480
  481 SHADPFGDDF FR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] PSI-BLAST 47.154902 Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)
    2 View Details [219..414] MSA 2.190996 View MSA. No confident structure predictions are available.
    3 View Details [415..492] MSA 1.16299 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.75270183218429 bayes_pls_golite062009
  • protein binding
    		•  1.30337811957526 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle