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Protein Overview: Pld-PD, Pld-PA, ...

General Information:
Name(s) found: Pld-PD / FBpp0085343 [FlyBase]
Pld-PA / FBpp0085341 [FlyBase]
Pld-PC / FBpp0085340 [FlyBase]
Pld-PB / FBpp0085339 [FlyBase]
Description(s) found:
Found 63 descriptions.
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  • The gene Phospholipase D is referred to in FlyBase by the symbol Dmel\Pld (CG12110, FBgn0033075). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2129529..2142771. It has the cytological map location 42A14. There is experimental evidence that it has the molecular function</span>: phospholipase D activity. There is experimental evidence that it is involved in the biological process</span>: Golgi organization; phototransduction; gastrulation involving germ band extension; cellularization; positive regulation of Golgi vesicle fusion to target membrane. 15 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; retina; gastrula embryo; pre-blastoderm embryo; eye photoreceptor cell; Golgi-associated vesicle; blastoderm embryo; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Phospholipase D is referred to in FlyBase by the symbol Dmel\Pld (CG12110, FBgn0033075). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2129529..2142771. It has the cytological map location 42A14. There is experimental evidence that it has the molecular function</span>: phospholipase D activity. There is experimental evidence that it is involved in the biological process</span>: Golgi organization; phototransduction; gastrulation involving germ band extension; cellularization; positive regulation of Golgi vesicle fusion to target membrane. 15 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; retina; gastrula embryo; pre-blastoderm embryo; eye photoreceptor cell; Golgi-associated vesicle; blastoderm embryo; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Phospholipase D is referred to in FlyBase by the symbol Dmel\Pld (CG12110, FBgn0033075). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2129529..2142771. It has the cytological map location 42A14. There is experimental evidence that it has the molecular function</span>: phospholipase D activity. There is experimental evidence that it is involved in the biological process</span>: Golgi organization; phototransduction; gastrulation involving germ band extension; cellularization; positive regulation of Golgi vesicle fusion to target membrane. 15 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; retina; gastrula embryo; pre-blastoderm embryo; eye photoreceptor cell; Golgi-associated vesicle; blastoderm embryo; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Phospholipase D is referred to in FlyBase by the symbol Dmel\Pld (CG12110, FBgn0033075). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2129529..2142771. It has the cytological map location 42A14. There is experimental evidence that it has the molecular function</span>: phospholipase D activity. There is experimental evidence that it is involved in the biological process</span>: Golgi organization; phototransduction; gastrulation involving germ band extension; cellularization; positive regulation of Golgi vesicle fusion to target membrane. 15 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; retina; gastrula embryo; pre-blastoderm embryo; eye photoreceptor cell; Golgi-associated vesicle; blastoderm embryo; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1278 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic vesicle [IDA]
    cellular_component [ND]
    Biological Process: cell communication [IEA]
    Golgi organization [IMP]
    metabolic process [IEA]
    positive regulation of Golgi vesicle fusion to target membrane [IMP]
    phototransduction [IMP]
    cellularization [IMP]
    gastrulation involving germ band extension [IMP]
    Molecular Function: protein binding [IEA]
    phosphoinositide binding [IEA]
    phospholipase D activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADAGTVGGA LPPYALTNSD EEHGSGEEDA SEENSNNEEG EGVFRDCTDE AVVEHHNRCL  60
   61 PEFQFSLVDS EYDETLAFPD SVTILSNVGD KPVLVERKET DDDEEEFDDE ENNSVVLRHE 120
  121 IPFTSIYGPS VKFNSFQRKV FIPGREIHVR IVDTERSVTT HLLNPNLYTI ELTHGPFKWT 180
  181 IKRRYKHFNS LHQQLSFFRT SLNIPFPSRS HKEKRTTLKA TAREMADEST LKDLPSHTKV 240
  241 KQTSTPLRAE GRSSKIAGSN ANNAMAMISP NHSSILAGLT PRRIQKKRKK KKKRKLPRFP 300
  301 NRPESLVTVE NLSVRIKQLE DYLYNLLNIS LYRSHHETLN FVEVSNVSFV PGMGIKGKEG 360
  361 VILKRTGSTR PGQAGCNFFG CFQKNCCVRC NYFCSDVVCG TWRNRWFFVK ETCFGYIRPT 420
  421 DGSIRAVILF DQGFDVSTGI YQTGMRKGLQ VLTNNRHIVL KCWTRRKCKE WMQYLKNTAN 480
  481 SYARDFTLPN PHMSFAPMRA NTHATWYVDG AQYMSAVADG LEAALEEIYI ADWWLSPEIY 540
  541 MKRPALDGDY WRLDKILLRK AEQGVRVFVL LYKEVEMALG INSYYSKSTL AKHENIKVMR 600
  601 HPDHARGGIL LWAHHEKIVV IDQTYAFMGG IDLCYGRWDD HHHRLTDLGS ISTSSFSGST 660
  661 RRTPSLYFTK DDTDSAFGSR KSSRNAHYDT SAKERPPSPP PDEPNTSIEL KTLKPGDRLL 720
  721 IPSTLVSSPG ETPAESGIAL EGMKLNTPEM ERKNVLDRLK NNAMKGARMG KDFMHRLTAT 780
  781 ETEEKSAEVY TIESEEATDH EVNLNMASGG QEVAITTSST QILSEFCGQA KYWFGKDYSN 840
  841 FILKDWMNLN SPFVDIIDRT TTPRMPWHDV GLCVVGTSAR DVARHFIQRW NAMKLEKLRD 900
  901 NTRFPYLMPK SYHQVRLNPN IQQNRQQRVT CQLLRSVSAW SCGFIEADLV EQSIHDAYIQ 960
  961 TITKAQHYVY IENQFFITMQ LGMGVPGAYN NVRNQIGETL FKRIVRAHKE RKPFRVYVIM1020
 1021 PLLPGFEGDV GGSTGIAVRA ITHWNYASIS RGRTSILTRL QEAGIANPEN YISFHSLRNH1080
 1081 SFLNNTPITE LIYVHSKLLI ADDRVVICGS ANINDRSMIG KRDSEIAAIL MDEEFEDGRM1140
 1141 NGKKYPSGVF AGRLRKYLFK EHLGLLESEG SSRSDLDIND PVCEKFWHGT WRRISMQNTE1200
 1201 IYDEVFKCIP TDFVKTFASL RKYQEEPPLA KTAPDLAANR ANDIQGYLVD LPLEFLNKEV1260
 1261 LTPPGTSKEG LIPTSVWT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..496] FFAS03 1.21 No description for 2elbA was found.
    2 View Details [497..688] PSI-BLAST 12.0 Phospholipase D
    3 View Details [689..1166] FFAS03 5.18 Tungstate-inhibited phospholipase D from Streptomyces sp. strain PMF.
    4 View Details [1167..1278] MSA 1.097994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  3.00808514157552 bayes_pls_golite062009
  • binding
    		•  2.73312450062269 bayes_pls_golite062009
  • receptor binding
    		•  1.08105010827764 bayes_pls_golite062009
  • phospholipid binding
    		•  0.321675464224877 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.252585156587152 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0702712292224799 bayes_pls_golite062009
  • transporter activity
    		•  0.0450763235722115 bayes_pls_golite062009
  • actin binding
    		•  0.0296832275351824 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  1.4657010373022 bayes_pls_golite062009
  • binding
    		•  1.43017855216152 bayes_pls_golite062009
  • kinase activity
    		•  0.408395249149739 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.127105742770319 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  1.47229278823338 bayes_pls_golite062009
  • binding
    		•  1.44495853135222 bayes_pls_golite062009
  • kinase activity
    		•  0.21075650005345 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle