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Protein Overview: RFC1

General Information:
Name(s) found: RFC1 [HGNC (HUGO)]
Description(s) found:
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  • gi|56757608|sp|P35251.4|RFC1_HUMAN RecName: Full=Replication factor C subunit 1; AltName: Full=Activator 1 subunit 1; AltName: Full=Replication factor C large subunit; AltName: Full=RF-C 140 kDa subunit; AltName: Full=Activator 1 140 kDa subunit; Short=A1 [NCBI NR]
  • gi|52632416|gb|AAH35297.1| Replication factor C (activator 1) 1, 145kDa [Homo sapiens] [NCBI NR]
  • gi|158256656|dbj|BAF84301.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119613329|gb|EAW92923.1| replication factor C (activator 1) 1, 145kDa, isoform CRA_b [Homo sapiens] [NCBI NR]
  • replication factor C (activator 1) 1, 145kDa [HGNC (HUGO)]
  • Replication factor C subunit 1 OS=Homo sapiens GN=RFC1 PE=1 SV=4 [Swiss-Prot]
  • Replication factor C large subunit [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Activator 1 140 kDa subunit (Replication factor C large subunit) (A1 140 kDa subunit) (RF-C 140 kDa subunit) (Activator 1 large subunit) (DNA-binding protein PO-GA) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Activator 1 140 kDa subunit [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_002913) replication factor C large subunit; activator 1, 140 kDa subunit; DNA-binding protein PO-GA; replication factor C1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Replication factor C (activator 1) 1, 145kDa [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • Replication factor C subunit 1 (Activator 1 subunit 1) (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (DNA-binding protein PO-GA) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • replication factor C (activator 1) 1, 145kDa, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Replication factor C subunit 1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=RFC1 Isoform 1 of Replication factor C subunit 1 [human-ipi-250309-contam.fasta]
  • Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA) [nr-271106-contam.fasta]
  • IPI:IPI00375358.2|SWISS-PROT:P35251-1|TREMBL:A8K6E7|ENSEMBL:ENSP00000371321|VEGA:OTTHUMP00000125201 Tax_Id=9606 Gene_Symbol=RFC1 Isoform 1 of Replication factor C subunit 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=RFC1 Isoform 1 of Replication factor C subunit 1 ENSG00000035928 IPI00748797 IPI00375359 IPI00375358 IPI00382816 [drosphohumanreversed.fasta]
  • P35251;A8K6E7;Q5XKF5;Q6PKU0;Q86V41;Q86V46; RecName: Full=Replication factor C subunit 1; AltName: Full=Activator 1 subunit 1; AltName: Full=Replication factor C large subunit; AltName: Full=Replication factor C 140 kDa subunit; AltName: Full=Activator 1 140 kDa subunit; AltName: Full=Activator 1 large subunit; AltName: Full=DNA-binding protein PO-GA; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Replication factor C subunit 1 OS=Homo sapiens GN=RFC1 [011711_HMR.fasta]
  • IPI:IPI00375358.2|SWISS-PROT:P35251-1|ENSEMBL:ENSP00000371321|VEGA:OTTHUMP00000125201 Tax_Id=9606 Gene_Symbol=RFC1 Isoform 1 of Replication factor C subunit 1 [ipi.HUMAN.fasta.20100406]
  • IPI:IPI00375358.2|SWISS-PROT:P35251-1|ENSEMBL:ENSP00000371321|REFSEQ:NP_001191676|VEGA:OTTHUMP00000125201 Tax_Id=9606 Gene_Symbol=RFC1 Isoform 1 of Replication factor C subunit 1 [ipi.HUMAN.20110912.fasta]
  • Replication factor C subunit 1 GN=RFC1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 1148 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIRKFFGVI PSGKKLVSET VKKNEKTKSD EETLKAKKGI KEIKVNSSRK EDDFKQKQPS  60
   61 KKKRIIYDSD SESEETLQVK NAKKPPEKLP VSSKPGKISR QDPVTYISET DEEDDFMCKK 120
  121 AASKSKENGR STNSHLGTSN MKKNEENTKT KNKPLSPIKL TPTSVLDYFG TGSVQRSNKK 180
  181 MVASKRKELS QNTDESGLND EAIAKQLQLD EDAELERQLH EDEEFARTLA MLDEEPKTKK 240
  241 ARKDTEAGET FSSVQANLSK AEKHKYPHKV KTAQVSDERK SYSPRKQSKY ESSKESQQHS 300
  301 KSSADKIGEV SSPKASSKLA IMKRKEESSY KEIEPVASKR KENAIKLKGE TKTPKKTKSS 360
  361 PAKKESVSPE DSEKKRTNYQ AYRSYLNREG PKALGSKEIP KGAENCLEGL IFVITGVLES 420
  421 IERDEAKSLI ERYGGKVTGN VSKKTNYLVM GRDSGQSKSD KAAALGTKII DEDGLLNLIR 480
  481 TMPGKKSKYE IAVETEMKKE SKLERTPQKN VQGKRKISPS KKESESKKSR PTSKRDSLAK 540
  541 TIKKETDVFW KSLDFKEQVA EETSGDSKAR NLADDSSENK VENLLWVDKY KPTSLKTIIG 600
  601 QQGDQSCANK LLRWLRNWQK SSSEDKKHAA KFGKFSGKDD GSSFKAALLS GPPGVGKTTT 660
  661 ASLVCQELGY SYVELNASDT RSKSSLKAIV AESLNNTSIK GFYSNGAASS VSTKHALIMD 720
  721 EVDGMAGNED RGGIQELIGL IKHTKIPIIC MCNDRNHPKI RSLVHYCFDL RFQRPRVEQI 780
  781 KGAMMSIAFK EGLKIPPPAM NEIILGANQD IRQVLHNLSM WCARSKALTY DQAKADSHRA 840
  841 KKDIKMGPFD VARKVFAAGE ETAHMSLVDK SDLFFHDYSI APLFVQENYI HVKPVAAGGD 900
  901 MKKHLMLLSR AADSICDGDL VDSQIRSKQN WSLLPAQAIY ASVLPGELMR GYMTQFPTFP 960
  961 SWLGKHSSTG KHDRIVQDLA LHMSLRTYSS KRTVNMDYLS LLRDALVQPL TSQGVDGVQD1020
 1021 VVALMDTYYL MKEDFENIME ISSWGGKPSP FSKLDPKVKA AFTRAYNKEA HLTPYSLQAI1080
 1081 KASRHSTSPS LDSEYNEELN EDDSQSDEKD QDAIETDAMI KKKTKSSKPS KPEKDKEPRK1140
 1141 GKGKSSKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] MSA 3.183996 View MSA. No confident structure predictions are available.
    2 View Details [156..301] MSA 1.240993 View MSA. No confident structure predictions are available.
    3 View Details [302..898] PSI-BLAST 56.30103 VCP/p97
    4 View Details [899..927] PSI-BLAST 49.39794 Replication factor C
    5 View Details [928..1148] PSI-BLAST 77.0 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle