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Protein Overview: PARP1

General Information:
Name(s) found: PARP1 [HGNC (HUGO)]
Description(s) found:
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  • pir||A29725 NAD ADP-ribosyltransferase (EC 2.4.2.30), nuclear - human [NCBI NR]
  • gi|55959449|emb|CAI12102.1| poly (ADP-ribose) polymerase 1 [Homo sapiens] [NCBI NR]
  • gi|55663671|emb|CAH70215.1| poly (ADP-ribose) polymerase 1 [Homo sapiens] [NCBI NR]
  • gi|21693601|gb|AAM75364.1|AF524947_1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) [Homo sapiens] [NCBI NR]
  • gi|178190|gb|AAA51663.1| NAD+ ADP-ribosyltransferase [NCBI NR]
  • gi|156523968|ref|NP_001609.2| poly (ADP-ribose) polymerase family, member 1 [Homo sapiens] [NCBI NR]
  • gi|130781|sp|P09874.4|PARP1_HUMAN RecName: Full=Poly [ADP-ribose] polymerase 1; Short=PARP-1; AltName: Full=ADPRT; AltName: Full=NAD(+) ADP-ribosyltransferase 1; AltName: Full=Poly[ADP-ribose] synthetase 1 [NCBI NR]
  • gi|119590190|gb|EAW69784.1| poly (ADP-ribose) polymerase family, member 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119590189|gb|EAW69783.1| poly (ADP-ribose) polymerase family, member 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • poly (ADP-ribose) polymerase 1 [HGNC (HUGO)]
  • Poly [ADP-ribose] polymerase 1 OS=Homo sapiens GN=PARP1 PE=1 SV=4 [Swiss-Prot]
  • ADP-ribosyltransferase (NAD+\; poly (ADP-ribose) polymerase) [Homo sapiens]gi|21693601|gb|AAM75364.1| ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) [Homo sapiens]gi|627553|pir||A29725 NAD ADP-ribosyltransferase (EC 2.4.2.30), nuclear - hum [nrdb_11152004_Chlamydomonas]
  • Poly [ADP-ribose] polymerase-1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase-1) (Poly[ADP-ribose] synthetase-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • poly (ADP-ribose) polymerase family, member 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Poly [ADP-ribose] polymerase 1 (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • poly (ADP-ribose) polymerase family, member 1, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • NAD+ ADP-ribosyltransferase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RecName: Full=Poly [ADP-ribose] polymerase 1; Short=PARP-1; AltName: Full=ADPRT; AltName: Full=NAD(+) ADP-ribosyltransferase 1; AltName: Full=Poly[ADP-ribose] synthetase 1 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PARP1 Poly [ADP-ribose] polymerase 1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00449049.5|SWISS-PROT:P09874|TREMBL:B1ANJ4;B2R5W3;B4E0E1;Q05D33;Q96P95|ENSEMBL:ENSP00000355759|REFSEQ:NP_001609|H-INV:HIT000195479|VEGA:OTTHUMP00000035663 Tax_Id=9606 Gene_Symbol=PARP1 Poly [ADP-ribose] polymerase 1 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Poly [ADP-ribose] polymerase 1 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PARP1 Poly [ADP-ribose] polymerase 1 ENSG00000143799 IPI00478427 IPI00477173 IPI00449049 [drosphohumanreversed.fasta]
  • P09874;B1ANJ4;Q8IUZ9; RecName: Full=Poly [ADP-ribose] polymerase 1; AltName: Full=NAD(+) ADP-ribosyltransferase 1; AltName: Full=Poly[ADP-ribose] synthase 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Poly [ADP-ribose] polymerase 1 OS=Homo sapiens GN=PARP1 [011711_HMR.fasta]
  • IPI:IPI00449049.5|SWISS-PROT:P09874|TREMBL:B2R5W3;Q05D33;Q6PJL0;Q96P95|ENSEMBL:ENSP00000355759|REFSEQ:NP_001609|H-INV:HIT000195479|VEGA:OTTHUMP00000035663 Tax_Id=9606 Gene_Symbol=PARP1 Poly [ADP-ribose] polymerase 1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PARP1 Synonyms=ADPRT|ADPRT 1|ADPRT1|PARP|PARP-1|PPOL|pADPRT-1 poly [ADP-ribose] polymerase 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00449049.5|SWISS-PROT:P09874|TREMBL:B2R5W3|ENSEMBL:ENSP00000355759|REFSEQ:NP_001609|H-INV:HIT000195479|VEGA:OTTHUMP00000035663 Tax_Id=9606 Gene_Symbol=PARP1 Poly [ADP-ribose] polymerase 1 [ipi.HUMAN.20110912.fasta]
  • Poly [ADP-ribose] polymerase 1 GN=PARP1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Poly (ADP-ribose) polymerase family, member 1, isoform CRA_a OS=Homo sapiens GN=PARP1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 1014 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV  60
   61 GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD GIGSKAEKTL GDFAAEYAKS 120
  121 NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ LGMIDRWYHP GCFVKNREEL GFRPEYSASQ 180
  181 LKGFSLLATE DKEALKKQLP GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA 240
  241 QNDLIWNIKD ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 300
  301 QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV KKQDRIFPPE 360
  361 TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK LSRNKDEVKA MIEKLGGKLT 420
  421 GTANKASLCI STKKEVEKMN KKMEEVKEAN IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP 480
  481 WGAEVKAEPV EVVAPRGKSG AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE 540
  541 HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 600
  601 LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLTVNPG 660
  661 TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV 720
  721 SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KVEMLDNLLD IEVAYSLLRG 780
  781 GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE 840
  841 REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 900
  901 VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA 960
  961 NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] PSI-BLAST 41.0 No description for 2dmjA was found.
    2 View Details [95..224] PSI-BLAST 33.69897 Solution structure of the second Zn-finger domain of poly(ADP-ribose) polymerase-1
    3 View Details [225..376] Pfam 34.823909 No description for PF08063.3 was found. No confident structure predictions are available.
    4 View Details [377..507] PSI-BLAST 13.09691 Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1
    5 View Details [508..645] PSI-BLAST 37.522879 Solution structure of WGR domain of poly(ADP-ribose) polymerase-1
    6 View Details [646..1014] PSI-BLAST 150.0 THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH CARBA-NAD


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle