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Protein Overview: MBHM_ECOLI

General Information:
Name(s) found: MBHM_ECOLI [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Hydrogenase-2 large chain precursor (EC 1.12.99.6) (NiFe hydrogenase) (Membrane-bound hydrogenase 2 large subunit) (HYD2) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 567 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRITIDPV TRIEGHLRID CEIENGVVSK AWASGTMWRG MEEIVKNRDP RDAWMIVQRI  60
   61 CGVCTTTHAL SSVRAAESAL NIDVPVNAQY IRNIILAAHT THDHIVHFYQ LSALDWVDIT 120
  121 SALQADPTKA SEMLKGVSTW HLNSPEEFTK VQNKIKDLVA SGQLGIFANG YWGHPAMKLP 180
  181 PEVNLIAVAH YLQALECQRD ANRVVALLGG KTPHIQNLAV GGVANPINLD GLGVLNLERL 240
  241 MYIKSFIDKL SDFVEQVYKV DTAVIAAFYP EWLTRGKGAV NYLSVPEFPT DSKNGSFLFP 300
  301 GGYIENADLS SYRPITSHSD EYLIKGIQES AKHSWYKDEA PQAPWEGTTI PAYDGWSDDG 360
  361 KYSWVKSPTF YGKTVEVGPL ANMLVKLAAG RESTQNKLNE IVAIYQKLTG NTLEVAQLHS 420
  421 TLGRIIGRTV HCCELQDILQ NQYSALITNI GKGDHTTFVK PNIPATGEFK GVGFLEAPRG 480
  481 MLSHWMVIKD GIISNYQAVV PSTWNSGPRN FNDDVGPYEQ SLVGTPVADP NKPLEVVRTI 540
  541 HSFDPCMACA VHVVDADGNE VVSVKVL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..567] PSI-BLAST 143.0 Nickel-iron hydrogenase, large subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on hydrogen as donor
    		•  6.92862518539575 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  3.63852106070173 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  3.63852106070173 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.2672032605265 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  2.70075876201392 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  2.4952454159327 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors
    		•  2.45015987642707 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.19558031681108 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.05566803830683 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.80355547790706 bayes_pls_golite062009
  • catalytic activity
    		•  1.13542026154948 bayes_pls_golite062009
  • binding
    		•  0.33259738701549 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle