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Protein Overview: ISPD_ECOLI

General Information:
Name(s) found: ISPD_ECOLI [Swiss-Prot]
Description(s) found:
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  • gi|882640|gb|AAA69257.1| ORF_f236 [NCBI NR]
  • pir||G65055 4-diphosphocytidyl-2C-methyl-D-erythritol synthase (EC 2.7.7.-) [similarity] - Escherichia coli (strain K-12) [NCBI NR]
  • gi|7239372|gb|AAF43207.1|AF230736_1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Escherichia coli] [NCBI NR]
  • gi|6978968|dbj|BAA90761.1| 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [Escherichia coli] [NCBI NR]
  • gi|2833415|sp|Q46893.3|ISPD_ECOLI RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase; AltName: Full=MEP cytidylyltransferase; Short=MCT; AltName: Full=CDP-ME synthetase [NCBI NR]
  • gi|17942575|pdb|1INI|A Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthetase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis, Complexed With Cdp-Me And Mg2+ [NCBI NR]
  • gi|15826378|pdb|1INJ|A Chain A, Crystal Structure Of The Apo Form Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthetase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis [NCBI NR]
  • gi|15826365|pdb|1I52|A Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis [NCBI NR]
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT) (CDP-ME synthetase) - Escherichia coli [Swiss-Prot]
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Escherichia coli K12]gi|1789104|gb|AAC75789.1| 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; 4-diphosphocytidyl-2C-methyl-D-erythrit [nrdb_11152004_Chlamydomonas]
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT) (CDP-ME synthetase) [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • Chain A, Crystal Structure Of The Apo Form Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthetase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis [nr-271106-contam.fasta]
  • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Escherichia coli] [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthetase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis, Complexed With Cdp-Me And Mg2+ [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me) Synthase (Ygbp) Involved In Mevalonate Independent Isoprenoid Biosynthesis [nr-271106-contam.fasta]
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Escherichia coli (strain K12) GN=ispD PE=1 SV=3 [uniprot-Ecoli-reviewed-110511.fasta]
    • Organism: Escherichia coli
    Length: 236 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATTHLDVCA VVPAAGFGRR MQTECPKQYL SIGNQTILEH SVHALLAHPR VKRVVIAISP  60
   61 GDSRFAQLPL ANHPQITVVD GGDERADSVL AGLKAAGDAQ WVLVHDAARP CLHQDDLARL 120
  121 LALSETSRTG GILAAPVRDT MKRAEPGKNA IAHTVDRNGL WHALTPQFFP RELLHDCLTR 180
  181 ALNEGATITD EASALEYCGF HPQLVEGRAD NIKVTRPEDL ALAEFYLTRT IHQENT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] PSI-BLAST 48.522879 4-diphosphocytidyl-2-c-methylerythritol (CDP-me) synthase (YgbP)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
    		•  2.01680144494637 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • transferase activity
    		•  1.47184463413038 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.03393419806381 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.983416157001861 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.651454753851031 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  0.423789091098118 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.361674579616957 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle