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Protein Overview: vps-34

General Information:
Name(s) found: vps-34 / CE37739 [WormBase]
Description(s) found:
Found 12 descriptions.
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  • WBGene00006932 locus:vps-34 status:Partially_confirmed UniProt:Q5TYK8 protein_id:AAV58894.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 720 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nuclear outer membrane [IDALink to PubMed article]
    Biological Process: nuclear envelope organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of protein secretion [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    phosphoinositide-mediated signaling [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    ecdysis, collagen and cuticulin-based cuticle [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IEALink to PubMed article]
    regulation of endocytosis [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: inositol or phosphatidylinositol kinase activity [IEALink to PubMed article]
    phosphotransferase activity, alcohol group as acceptor [IEALink to PubMed article]
    1-phosphatidylinositol-3-kinase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPGMRATPT ESFSFVYSCD LQTNVQVKVA EFEGIFRDVL NPVRRLNQLF AEITVYCNNQ  60
   61 QIGYPVCTSF HTPPDSSQLA RQKLIQKWNE WLTLPIRYSD LSRDAFLHIT IWEHEDDEIV 120
  121 NNSTFSRRLV AQSKLSMFSK RGILKSGVID VQMNVSTTPD PFVKQPETWK YSDAWGDEID 180
  181 LLFKQVTRQS RGLVEDVPWL DPFASRRIEM IRAKYKYSSP DRHVFLVLEM AAIRLGPTFY 240
  241 KVVYYEDETK NMRVSTSVNG GVGIVSACTR YCVADPELLL ESLAEVKHSA MTRRIRDVED 300
  301 ERHRQVKPNK QAKDRLETIV NLPSSQVLTR EQRDLVWKFR HYLRQFPKAL NKYLRSVNWV 360
  361 HPQEVKTALA LMNDWELIEA EDALELLSSA FTHPAVRAYS VSRLLEAASP EQVLLYLPQL 420
  421 VQALKYEQGQ QLPEEGNPVP VVSEEEGKIP SVATTPTEEL EGRDMTVVTK KEARKAASGD 480
  481 LATFLIDYAL ASPKVSNYLY WHLKTEIEST KESKEEHSKM YQNIQDRLME ALVKRPDTRA 540
  541 QVDSLHQQQI FVEDLIILMN EAKARGGRLN ESKSAEFRTM LSRAKHMLDL KGVHLPLDPS 600
  601 FRLSSVIPDT ASFFKSEMMP AKISFKVLQP NGKADRNIPE EYTVIFKTGD DLRQDQLIQQ 660
  661 MVRLIDIILK KGQLDLKLTP YLVRNIYIYI KFVEEIVNIA KKNKSRKSTR KIYEILLKFI 720
  721

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] MSA 4.068996 View MSA. No confident structure predictions are available.
    2 View Details [102..720] PSI-BLAST 105.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle