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Protein Overview: gi|24375542, gi|...

General Information:
Name(s) found: gi|24375542 [NCBI NR]
gi|24350421 [NCBI NR]
Description(s) found:
Found 5 descriptions.
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  • gi|24375542|ref|NP_719585.1| bifunctional aspartate kinase II/homoserine dehydrogenase II [Shewanella oneidensis MR-1] [NCBI NR]
  • gi|24350421|gb|AAN57029.1|AE015837_1 aspartokinase II/homoserine dehydrogenase, methionine-sensitive [Shewanella oneidensis MR-1] [NCBI NR]
    • Organism: Shewanella oneidensis MR-1
    Length: 797 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: methionine biosynthetic process [ISSLink to PubMed article]
    lysine biosynthetic process via diaminopimelate [ISSLink to PubMed article]
    threonine biosynthetic process [ISSLink to PubMed article]
    Molecular Function: aspartate kinase activity [ISSLink to PubMed article]
    homoserine dehydrogenase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARCHLHKFG GSSLADADCY RRVAHILLTH GHSDDLVVVS AAGKTTNFLY KLLSLRDSNQ  60
   61 LWQEELQVLI SYQQGLIEQL LSNEQARDLR ERLTTDKAQL ISLLSLDVRN DYQISHVVSF 120
  121 GERWSARLMA ALLRESGVAA SHVDACSILV ADEAAVPQIR VQESRAKVQA LLAAHPNERL 180
  181 VITGFICANE RGDTLLLGRN GSDFSASLIA SLADIERVTI WTDVEGVFNA DPNKINDAKL 240
  241 LKSMSLAEAD RLARLGSPVL HSRTLQPLFN TEVSLAVRSS YASHTDFTLI APHSSSASAP 300
  301 VVTNLNAVVL FGFKIAGDVA SLLDQLVEAG LTPLAHWVSA HQRLELAYTA ENQKQVQKLL 360
  361 DAQAEALGIR DLQINTELGL VALVSADAEH YRRSFARLLS RDAKPLFSGD LSLVTLVPQS 420
  421 QVNLLTQKVH RRCAGPRKRI GVLLLGVGNI GEAWVKLFKS VSPSLNQELE AQVELVGLVT 480
  481 SSKALIKSKG VDLQSWQQEF DNEATPWQYE HLFEQLEQLN CDELIALDIS ASASLTLQYP 540
  541 EFFERGIHMV SANKLAGSGP LPFYRELKEQ LGYRRLFWRY NASCGAGLPI QHALNDLRNS 600
  601 GDSVEAVGGI FSGTLCWLFE KYDTSKPFSE LVIEARGLGI TEPDPRDDLS GRDMQRKLLI 660
  661 LAREIGLEIE LEDIELRSLV PAHLADIPLE QFLARIGELD DELLQQYGAA AEQNKVLRYV 720
  721 ASLDNSGAVL KAEVGLQWID ASHPYANLTP GDNVFVIRSA FYQGNPLIIR GPGAGREVTA 780
  781 AAVQSDLTQI CRDLLQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..435] PSI-BLAST 88.0 No description for 2hmfA was found.
    2 View Details [436..797] PSI-BLAST 64.522879 Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aspartate kinase activity
    		•  3.39058614295645 bayes_pls_golite062009
  • phosphotransferase activity, carboxyl group as acceptor
    		•  3.23203925555954 bayes_pls_golite062009
  • catalytic activity
    		•  3.20382750184555 bayes_pls_golite062009
  • amino acid kinase activity
    		•  2.69040298093296 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  2.58771218094881 bayes_pls_golite062009
  • transferase activity
    		•  2.54481238004476 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.89315414622708 bayes_pls_golite062009
  • kinase activity
    		•  1.84529070582231 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  1.7506777126472 bayes_pls_golite062009
  • acetylglutamate kinase activity
    		•  1.45784525332691 bayes_pls_golite062009
  • glutamate 5-kinase activity
    		•  0.537497646385449 bayes_pls_golite062009
    2
    Term Confidence Notes
  • aspartate-semialdehyde dehydrogenase activity
    		•  3.92511214237139 bayes_pls_golite062009
  • catalytic activity
    		•  2.91887313269429 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.86254373278283 bayes_pls_golite062009
  • dihydrodipicolinate reductase activity
    		•  2.74085594134831 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.19591951564949 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  1.07932840802619 bayes_pls_golite062009
  • phosphoglycerate dehydrogenase activity
    		•  0.815013397873281 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.23458869447046 bayes_pls_golite062009
  • N-acetyl-gamma-glutamyl-phosphate reductase activity
    		•  0.22364954992375 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.22262673350502 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase activity
    		•  0.0876163188309598 bayes_pls_golite062009
  • saccharopine dehydrogenase activity
    		•  0.0126684068691896 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle