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Protein Overview: gi|24348771, gi|...

General Information:
Name(s) found: gi|24374246 [NCBI NR]
gi|24348771 [NCBI NR]
Description(s) found:
Found 4 descriptions.
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  • gi|24374246|ref|NP_718289.1| DNA topoisomerase I [Shewanella oneidensis MR-1] [NCBI NR]
  • gi|24348771|gb|AAN55733.1|AE015710_1 DNA topoisomerase I [Shewanella oneidensis MR-1] [NCBI NR]
    • Organism: Shewanella oneidensis MR-1
    Length: 878 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA topological change [ISSLink to PubMed article]
    DNA unwinding involved in replication [ISSLink to PubMed article]
    Molecular Function: DNA binding [ISSLink to PubMed article]
    DNA topoisomerase type I activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKSLVIVES PAKAKTINKY LGKEFIVKSS VGHIRDLPTS SISDGTEKVK SAAEVKKMSP  60
   61 EEKARYKKVK DHQALVSRMG VNPEKGWAAK YQILPGKEKV VKELQALADS ADQIYLATDL 120
  121 DREGEAIAWH LQEVIGGDPS RYQRVVFNEI TKSAIQEAFS KPASLDTNMV NAQQARRFLD 180
  181 RVVGFMVSPL LWKKVARGLS AGRVQSVAVR LVVERESEIK AFVPEEFWDV HAQLNTPSSE 240
  241 ALRMEVVKYL DSAFEPTNEQ QALAAVQALS SASFKVIARE DKATQSKPSA PFITSTLQQA 300
  301 ASTRLGFGVK KTMMMAQRLY EAGHITYMRT DSTNLSQEAL DSVREMIGKE YGAKYLPAEP 360
  361 IRYGSKEGAQ EAHEAIRPSN VKVEAAALTD MERDAQRLYE LIWRQFVSCQ MTPALYDATK 420
  421 LTVKAADYEL KATGRILRFD GWTRVQTAIK KKNEEDNTLP AVNEGDVLSL VELEPKQHFT 480
  481 KPPARYSEAS LVKELEKRGI GRPSTYATII STIQERGYVK VENRRFYAEK MGEIVSERLV 540
  541 NSFAELMSYD FTASMEQTLD DVAKGELDWK KVLDGFYADF TKQLEKAELA PEEGGMRLNQ 600
  601 MVMTNIKCPT CGRPMGIRTG TTGVFLGCSG YELPPKERCK TTMNLTPGIE AISDSEDAET 660
  661 DALRAKHRCG ICGTAMDSYL LDEKRKLHVC GNNPVCEGYE VEEGQFKIKG YEGPLIECDR 720
  721 CGHDMELKNG RFGKYFGCTN EECKNTRKLL KNGEAAPPKE DPIYLPELKC SKSDAHFVLR 780
  781 DGAAGIFLAA STFPKSRETR APLVEELVKY REFLWPKYQY LADAPIADDD GNKAVVKFSR 840
  841 KTKDQYVATE VDGKATGWSA HYVNGKWVSE SSAKKAKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..604] PSI-BLAST 1000.0 AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
    2 View Details [605..751] FFAS03 1.28 No description for 2gaiA was found.
    3 View Details [752..878] PSI-BLAST 48.0 C-TERMINAL DOMAIN OF ESCHERICHIA COLI TOPOISOMERASE I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  9.28485802237784 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  6.20416707013367 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.37048693883188 bayes_pls_golite062009
  • DNA binding
    		•  3.2732257752308 bayes_pls_golite062009
  • binding
    		•  3.07618319631815 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA primase activity
    		•  3.07516234808151 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  2.45202527906689 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.79551532005706 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.79551532005706 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977281907364794 bayes_pls_golite062009
  • binding
    		•  0.827218793613898 bayes_pls_golite062009
  • catalytic activity
    		•  0.434839928397784 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.33473177315365 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0647934199260571 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle