Protein Overview: MRD1_YEAST

General Information:
Name(s) found:	MRD1_YEAST [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	Multiple RNA-binding domain-containing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRD1 PE=1 SV=1 [Swiss-Prot] Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains [Saccharomyces cerevisiae] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
Organism:	Saccharomyces cerevisiae S288c
Length:	887 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRIIVKGLP VYLTDDNLRE HFTKRLRQKH SHQAVNGSGP DLITDVKILR DRNGESRRFG  60
   61 FIGYRNEEDA FDAVEYFNGS FINTSKIEVS MAKSFADPRV PQPMKEKRRE ALKRFREKEE 120
  121 KLLQEENRKK KKVDENKHSN IDDEIRKNKQ LQEFMETMKP SSQVTSWEKV GIDKSIEDEK 180
  181 LKREEEDSSV QGNSLLAHAL ALKEENNKDE APNLVIENES DDEYSALNRN RDEDQEDAGE 240
  241 EEKMISISNL KDTDIGLVND DANSDEKENE KRRNLAQDEK VSDLDWFKQR RVRIKESEAE 300
  301 TREKSSSYAT EQNESLDTKK EEQPERAVPQ KTDEELAIEK INQTGRLFLR NILYTSKEED 360
  361 FRKLFSPFGE LEEVHVALDT RTGQSKGFAY VLFKDSKNAV NAYVELDKQI FQGRLLHILP 420
  421 GEEKKSHRLD EFDLKNMPLK KQKELKRKAA ASRQTFSWNS LYMNQDAVLG SVAAKLGLEK 480
  481 SQLIDAENSS SAVKQALAEA HVIGDVRKYF ESKGVDLTKF SQLKSTNQRD DKVILVKNFP 540
  541 FGTTREELGE MFLPYGKLER LLMPPAGTIA IVQFRDTTSA RAAFTKLSYK RFKDGIIYLE 600
  601 RGPKDCFTKP AEADDLINNT SAKEEENPVE VKPSSNDLME ANKDVTEGSS NAHDEDVIDG 660
  661 PTVSIFIKNL NFSTTNQNLT DRFKVFTGFV VAQVKTKPDP KHQGKTLSMG FGFVEFRTKE 720
  721 QANAVIAAMD GTVIDGHKIQ LKLSHRQASQ SGNTKTKSNK KSGKIIVKNL PFEATRKDVF 780
  781 ELFNSFGQLK SVRVPKKFDK SARGFAFVEF LLPKEAENAM DQLHGVHLLG RRLVMQYAEE 840
  841 DAVDAEEEIA RMTKKVRKQV ATNEMAALRN GGGRKKLDVD DEENEGF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..113]	PSI-BLAST	7.0	Nucleolin
2	View Details	[114..316]	MSA	1.132995	View MSA. No confident structure predictions are available.
3	View Details	[317..423]	PSI-BLAST	121.232149	Poly(A)-binding protein
4	View Details	[424..528]	PSI-BLAST	121.232149	Poly(A)-binding protein
5	View Details	[529..627]	PSI-BLAST	41.980454	Nucleolin
6	View Details	[628..754]	PSI-BLAST	97.40824	Nuclear ribonucleoprotein A1 (RNP A1, UP1)
7	View Details	[755..887]	PSI-BLAST	97.40824	Nuclear ribonucleoprotein A1 (RNP A1, UP1)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
RNA binding	6.04120049976231	bayes_pls_golite062009
mRNA binding	4.29904003387927	bayes_pls_golite062009
nucleic acid binding	3.81920018903278	bayes_pls_golite062009
binding	3.44552682116509	bayes_pls_golite062009
	3.36965439092178	bayes_pls_golite062009
single-stranded RNA binding	2.32565125258004	bayes_pls_golite062009
poly-pyrimidine tract binding	1.99190411806363	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
transcription regulator activity	1.07788694919471	bayes_pls_golite062009
protein binding	1.02232785292059	bayes_pls_golite062009
DNA binding	0.978604858165557	bayes_pls_golite062009
snoRNA binding	0.87536768969411	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.764716918216811	bayes_pls_golite062009
snRNA binding	0.45487108214667	bayes_pls_golite062009
transcription factor activity	0.234742017105535	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
RNA binding	6.04120049976231	bayes_pls_golite062009
mRNA binding	4.29904003387927	bayes_pls_golite062009
nucleic acid binding	3.81920018903278	bayes_pls_golite062009
binding	3.44552682116509	bayes_pls_golite062009
	3.36965439092178	bayes_pls_golite062009
single-stranded RNA binding	2.32565125258004	bayes_pls_golite062009
poly-pyrimidine tract binding	1.99190411806363	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
transcription regulator activity	1.07788694919471	bayes_pls_golite062009
protein binding	1.02232785292059	bayes_pls_golite062009
DNA binding	0.978604858165557	bayes_pls_golite062009
snoRNA binding	0.87536768969411	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.764716918216811	bayes_pls_golite062009
snRNA binding	0.45487108214667	bayes_pls_golite062009
transcription factor activity	0.234742017105535	bayes_pls_golite062009

4

Term	Confidence	Notes
RNA binding	6.04120049976231	bayes_pls_golite062009
mRNA binding	4.29904003387927	bayes_pls_golite062009
nucleic acid binding	3.81920018903278	bayes_pls_golite062009
binding	3.44552682116509	bayes_pls_golite062009
	3.36965439092178	bayes_pls_golite062009
single-stranded RNA binding	2.32565125258004	bayes_pls_golite062009
poly-pyrimidine tract binding	1.99190411806363	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
transcription regulator activity	1.07788694919471	bayes_pls_golite062009
protein binding	1.02232785292059	bayes_pls_golite062009
DNA binding	0.978604858165557	bayes_pls_golite062009
snoRNA binding	0.87536768969411	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.764716918216811	bayes_pls_golite062009
snRNA binding	0.45487108214667	bayes_pls_golite062009
transcription factor activity	0.234742017105535	bayes_pls_golite062009

5

Term	Confidence	Notes
RNA binding	6.04120049976231	bayes_pls_golite062009
mRNA binding	4.29904003387927	bayes_pls_golite062009
nucleic acid binding	3.81920018903278	bayes_pls_golite062009
binding	3.44552682116509	bayes_pls_golite062009
	3.36965439092178	bayes_pls_golite062009
single-stranded RNA binding	2.32565125258004	bayes_pls_golite062009
poly-pyrimidine tract binding	1.99190411806363	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
transcription regulator activity	1.07788694919471	bayes_pls_golite062009
protein binding	1.02232785292059	bayes_pls_golite062009
DNA binding	0.978604858165557	bayes_pls_golite062009
snoRNA binding	0.87536768969411	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.764716918216811	bayes_pls_golite062009
snRNA binding	0.45487108214667	bayes_pls_golite062009
transcription factor activity	0.234742017105535	bayes_pls_golite062009

6

No functions predicted.

7

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle