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Protein Overview: EG10014

General Information:
Name(s) found: acrD / EG10014 [EcoGene]
Description(s) found:
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  • aminoglycoside/multidrug efflux system / Aminoglycoside efflux pump; RND-type transporter [EcoGene]
  • aminoglycoside/multidrug efflux system [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • aminoglycoside/multidrug efflux system [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 1037 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [IEA]
    plasma membrane [IEA]
    Biological Process: drug transmembrane transport [IMPLink to PubMed article]
    response to drug [IDALink to PubMed article]
    Molecular Function: drug:hydrogen antiporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANFFIDRPI FAWVLAILLC LTGTLAIFSL PVEQYPDLAP PNVRVTANYP GASAQTLENT  60
   61 VTQVIEQNMT GLDNLMYMSS QSSGTGQASV TLSFKAGTDP DEAVQQVQNQ LQSAMRKLPQ 120
  121 AVQNQGVTVR KTGDTNILTI AFVSTDGSMD KQDIADYVAS NIQDPLSRVN GVGDIDAYGS 180
  181 QYSMRIWLDP AKLNSFQMTA KDVTDAIESQ NAQIAVGQLG GTPSVDKQAL NATINAQSLL 240
  241 QTPEQFRDIT LRVNQDGSEV RLGDVATVEM GAEKYDYLSR FNGKPASGLG VKLASGANEM 300
  301 ATAELVLNRL DELAQYFPHG LEYKVAYETT SFVKASIEDV VKTLLEAIAL VFLVMYLFLQ 360
  361 NFRATLIPTI AVPVVLMGTF SVLYAFGYSV NTLTMFAMVL AIGLLVDDAI VVVENVERIM 420
  421 SEEGLTPREA TRKSMGQIQG ALVGIAMVLS AVFVPMAFFG GTTGAIYRQF SITIVAAMVL 480
  481 SVLVAMILTP ALCATLLKPL KKGEHHGQKG FFAWFNQMFN RNAERYEKGV AKILHRSLRW 540
  541 IVIYVLLLGG MVFLFLRLPT SFLPLEDRGM FTTSVQLPSG STQQQTLKVV EQIEKYYFTH 600
  601 EKDNIMSVFA TVGSGPGGNG QNVARMFIRL KDWSERDSKT GTSFAIIERA TKAFNQIKEA 660
  661 RVIASSPPAI SGLGSSAGFD MELQDHAGAG HDALMAARNQ LLALAAENPE LTRVRHNGLD 720
  721 DSPQLQIDID QRKAQALGVA IDDINDTLQT AWGSSYVNDF MDRGRVKKVY VQAAAPYRML 780
  781 PDDINLWYVR NKDGGMVPFS AFATSRWETG SPRLERYNGY SAVEIVGEAA PGVSTGTAMD 840
  841 IMESLVKQLP NGFGLEWTAM SYQERLSGAQ APALYAISLL VVFLCLAALY ESWSVPFSVM 900
  901 LVVPLGVIGA LLATWMRGLE NDVYFQVGLL TVIGLSAKNA ILIVEFANEM NQKGHDLFEA 960
  961 TLHACRQRLR PILMTSLAFI FGVLPMATST GAGSGGQHAV GTGVMGGMIS ATILAIYFVP1020
 1021 LFFVLVRRRF PLKPRPE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1037] PSI-BLAST 1000.0 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 5.76635084475529 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  5.26216058720248 bayes_pls_golite062009
    		• 4.79371622943198 bayes_pls_golite062009
  • transporter activity
    		•  1.3820077421337 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.24821957412828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.12397386858091 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle