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Protein Overview: EG12083

General Information:
Name(s) found: nuoB / EG12083 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • NADH:ubiquinone oxidoreductase, chain B / NADH:ubiquinone oxidoreductase subunit B, complex I; NADH dehydrogenase I [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 220 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane respiratory chain complex I [IDALink to PubMed article]
    NADH dehydrogenase complex [IDALink to PubMed article]
    [NOT]cytoplasm [IDALink to PubMed article]
    membrane [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: anaerobic respiration [IMPLink to PubMed article]
    electron transport coupled proton transport [IMPLink to PubMed article]
    photosynthesis, light reaction [IEA]
    oxidation reduction [IEA]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: oxidoreduction-driven active transmembrane transporter activity [IDALink to PubMed article]
    NADH dehydrogenase activity [IDALink to PubMed article]
    quinone binding [IEA]
    metal ion binding [IEA]
    iron ion binding [IEA]
    NADH dehydrogenase (ubiquinone) activity [IEA][IMPLink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYTLTRIDP NGENDRYPLQ KQEIVTDPLE QEVNKNVFMG KLNDMVNWGR KNSIWPYNFG  60
   61 LSCCYVEMVT SFTAVHDVAR FGAEVLRASP RQADLMVVAG TCFTKMAPVI QRLYDQMLEP 120
  121 KWVISMGACA NSGGMYDIYS VVQGVDKFIP VDVYIPGCPP RPEAYMQALM LLQESIGKER 180
  181 RPLSWVVGDQ GVYRANMQSE RERKRGERIA VTNLRTPDEI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 53.522879 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  13.9361001493201 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  12.823760326196 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  12.8237449606378 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  12.2946357205778 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  11.5463682902166 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.65509281399906 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  5.96984573452012 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  5.23135981388428 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  4.95810064745013 bayes_pls_golite062009
  • metal cluster binding
    		•  4.95810064745013 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor
    		•  1.94254997143399 bayes_pls_golite062009
  • catalytic activity
    		•  1.41356903593784 bayes_pls_golite062009
  • transporter activity
    		•  1.35313139085437 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  1.17664896715936 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  1.17664896715936 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.14096979892017 bayes_pls_golite062009
  • binding
    		•  0.666284431609449 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.3569377519136 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.345046820478722 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors
    		•  0.100407685917506 bayes_pls_golite062009
  • protein binding
    		•  0.0224428394870909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle