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Protein Overview: EG11784

General Information:
Name(s) found: grcA / EG11784 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • autonomous glycyl radical cofactor / Autonomous glycine radical cofactor; can reactivate pyruvate formate lyase after oxidative stress; induced by low pH or propionate; pyruvate formate lyase homolog, spare part for PFL [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 127 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: metabolic process [IEA]
    response to stress [IEA]
    Molecular Function: catalytic activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITGIQITKA ANDDLLNSFW LLDSEKGEAR CIVAKAGYAE DEVVAVSKLG DIEYREVPVE  60
   61 VKPEVRVEGG QHLNVNVLRR ETLEDAVKHP EKYPQLTIRV SGYAVRFNSL TPEQQRDVIA 120
  121 RTFTESL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] PSI-BLAST 33.69897 Pyruvate formate-lyase, PFL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.55459871885306 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
    		•  0.46730764989157 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups
    		•  0.453866191047343 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.428689336564751 bayes_pls_golite062009
  • ribonucleoside-diphosphate reductase activity
    		•  0.042444983124382 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle