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Protein Overview: EG10341

General Information:
Name(s) found: ftsI / EG10341 [EcoGene]
Description(s) found:
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  • transpeptidase involved in septal peptidoglycan synthesis; penicillin-binding protein 3 / Transpetidase, PBP3; penicillin-binding protein 3 involved in septal peptidoglycan synthesis [EcoGene]
  • transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    cell division site part [IDALink to PubMed article]
    intrinsic to plasma membrane [IDALink to PubMed article]
    Biological Process: cell division [IEA][IMPLink to PubMed article]
    peptidoglycan-based cell wall biogenesis [IEA]
    regulation of cell shape [IEA]
    response to drug [IDALink to PubMed article][IMPLink to PubMed article]
    peptidoglycan biosynthetic process [IEA]
    response to antibiotic [IEA]
    cellular cell wall organization [IEA]
    cell cycle [IEA]
    Molecular Function: protein binding [IGILink to PubMed article]
    peptidoglycan glycosyltransferase activity [IDALink to PubMed article][IEA][IMPLink to PubMed article]
    penicillin binding [IDALink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAAAKTQKP KRQEEHANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVKEGDMR  60
   61 SLRVQQVSTS RGMITDRSGR PLAVSVPVKA IWADPKEVHD AGGISVGDRW KALANALNIP 120
  121 LDQLSARINA NPKGRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG 180
  181 FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL 240
  241 QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNLSGTP KEAMRNRTIT 300
  301 DVFEPGSTVK PMVVMTALQR GVVRENSVLN TIPYRINGHE IKDVARYSEL TLTGVLQKSS 360
  361 NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG 420
  421 LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESIVRTVVHM MESVALPGGG 480
  481 GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASQPRFALVV VINDPQAGKY 540
  541 YGGAVSAPVF GAIMGGVLRT MNIEPDALTT GDKNEFVINQ GEGTGGRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..588] PSI-BLAST 102.0 PBP2x from Streptococcus pneumoniae strain 5259 with reduced susceptibility to beta-lactam antibiotics

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • serine-type D-Ala-D-Ala carboxypeptidase activity
    		•  3.12650314537616 bayes_pls_golite062009
  • serine-type carboxypeptidase activity
    		•  2.70174066798582 bayes_pls_golite062009
  • serine-type exopeptidase activity
    		•  2.69091897402517 bayes_pls_golite062009
  • drug binding
    		•  2.00030594135732 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  1.96547160092829 bayes_pls_golite062009
  • penicillin binding
    		•  1.46269268256076 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.44522375970439 bayes_pls_golite062009
  • binding
    		•  1.43165609051179 bayes_pls_golite062009
  • catalytic activity
    		•  0.767627914425245 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.163657050466595 bayes_pls_golite062009
  • protein binding
    		•  0.0666688846338231 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle